Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
Hum Exp Toxicol. 2010 Aug;29(8):653-8. doi: 10.1177/0960327109359638. Epub 2010 Jan 12.
Withania coagulans is used in indigenous system of medicine in several conditions, and its aqueous extract alone has reported antihyperglycemic activity. As per the principles of Indigenous System of Medicine, the combined use of aqueous and chloroform extracts of W coagulans fruits, containing multi-constituents, has been evaluated for the effect on blood glucose, lipid profile and body weight in type 2 diabetic rats. The aqueous and chloroform extracts were prepared by simple maceration and hot refluxing using Soxhlet apparatus, respectively. They were administered orally singly and concurrently as combination, once daily, a dose of 1 g kg(-1) for 14 days in different groups of normoglycemic and hyperglycemic rats. Orally normal saline 1 mL 100 g(-1), and Metformin 500 mg kg(-1), were used as control and standard, respectively. Aqueous extract showed highly significant (p < .01) decrease in the blood glucose (52%), triglyceride, total cholesterol, LDL and VLDL level and highly significant (p < .01) increase in HDL level. The antihyperglycemic effect was found slightly (6%) superior to metformin. The combination of aqueous and chloroform extracts showed highly significant (p < .01) decrease in the blood glucose (55%), triglyceride, total cholesterol, LDL and VLDL levels, and a highly significant (p < .01) increase in HDL level. The antihyperglycemic effect being better than Metformin and aqueous extracts, 9% and 3%, respectively.
睡茄被用于多种疾病的传统医学治疗中，其水提物已被报道具有降血糖活性。根据传统医学理论，水提物和氯仿提物联合使用，可同时作用于多种成分，用于 2 型糖尿病大鼠的血糖、血脂谱和体重的影响。水提物和氯仿提物分别采用简单的浸渍法和索氏提取法提取。正常血糖和高血糖大鼠分别每天灌胃 1 次，剂量为 1 g/kg，连续 14 天，分为正常组、模型组、阳性药组、水提物组、氯仿提物组、水提物+氯仿提物组。对照组灌胃生理盐水 1 mL/100 g，阳性药组灌胃二甲双胍 500 mg/kg。水提物组可显著降低（p<0.01）血糖（52%）、三酰甘油、总胆固醇、LDL 和 VLDL 水平，显著升高（p<0.01）HDL 水平。其降血糖作用略优于二甲双胍（6%）。水提物+氯仿提物组可显著降低（p<0.01）血糖（55%）、三酰甘油、总胆固醇、LDL 和 VLDL 水平，显著升高（p<0.01）HDL 水平。其降血糖作用优于二甲双胍和水提物，分别为 9%和 3%。
