石栗甲醇提取物的降血脂活性。

Hypolipidaemic activity of methanol extract of Aleurites moluccana.

作者信息

Pedrosa R C, Meyre-Silva C, Cechinel-Filho V, Benassi J C, Oliveira L F S, Zancanaro V, Dal Magro J, Yunes R A

机构信息

Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina - UFSC, Florianópolis - SC, Brazil.

出版信息

Phytother Res. 2002 Dec;16(8):765-8. doi: 10.1002/ptr.1046.

DOI:10.1002/ptr.1046

PMID:12458484

Abstract

The lipid-lowering action of the leaves of the Aleurites moluccana methanol extract was studied in Triton W-1339 and high-fat-diet fed rats. The serum lipids (total cholesterol, LDL- and HDL-cholesterol and triglycerides) and body weight were found to be lowered by A. moluccana (300 mg/kg, b.w.) in rats with Triton-induced hypercholesterolaemia and on a hyperlipaemic diet. The results suggest that the lipid lowering action of this natural product is mediated through inhibition of hepatic cholesterol biosynthesis and reduction of lipid absorption in the intestine.

摘要

在 Triton W - 1339 和高脂饮食喂养的大鼠中研究了油桐叶甲醇提取物的降脂作用。发现在 Triton 诱导的高胆固醇血症大鼠和高脂血症饮食条件下，油桐（300 mg/kg，体重）可降低血清脂质（总胆固醇、低密度脂蛋白和高密度脂蛋白胆固醇以及甘油三酯）和体重。结果表明，这种天然产物的降脂作用是通过抑制肝脏胆固醇生物合成和减少肠道脂质吸收来介导的。