Herrmann D, Jäger L, Hein G, Henzgen M, Schlenvoigt G
Department of Internal Medicine, Friedrich Schiller University Jena, FRG.
J Investig Allergol Clin Immunol. 1991 Oct;1(5):302-7.
The sera of 80 patients suffering from rheumatoid arthritis (RA)--30 of them with extraarticular manifestations (EAM) and 50 patients with articular disease only--of 25 patients with other joint diseases and of 30 normal healthy subjects, were analyzed for the presence of 1) IgE rheumatoid factors (IgE RF) by means of a solid phase radioimmunoassay and an ELISA, 2) IgM rheumatoid factors by using solid phase radioimmune techniques, and 3) circulating immune complexes (CIC) with the C1q binding test (C1q BT) and the solid phase conglutinin binding test (SPCBT). The best technique to discriminate RA patients with EAM from RA patients without EAM and patients with other articular diseases was the determination of IgE RF (73.3%, 38.0%, 0%, resp.) compared to IgM RF (86.7%, 78.0%, and 56.0%) and CIC (C1q BT: 80.0%, 66.0% and 45.0%; SPCBT: 46.7%, 22.0%, and 20.0%). The results suggest a certain role of IgE RF for diagnosis and a possible development of extraarticular manifestations in rheumatoid arthritis.
对80例类风湿关节炎（RA）患者——其中30例有关节外表现（EAM），50例仅有关节疾病——以及25例其他关节疾病患者和30名正常健康受试者的血清进行了分析，以检测以下物质的存在：1）通过固相放射免疫测定法和酶联免疫吸附测定法检测IgE类风湿因子（IgE RF）；2）使用固相放射免疫技术检测IgM类风湿因子；3）通过C1q结合试验（C1q BT）和固相凝集素结合试验（SPCBT）检测循环免疫复合物（CIC）。与IgM RF（分别为86.7%、78.0%和56.0%）和CIC（C1q BT：80.0%、66.0%和45.0%；SPCBT：46.7%、22.0%和20.0%）相比，鉴别有EAM的RA患者与无EAM的RA患者及其他关节疾病患者的最佳技术是检测IgE RF（分别为73.3%、38.0%、0%）。结果表明IgE RF在类风湿关节炎的诊断中具有一定作用，并且可能与关节外表现的发生有关。
