Yoshinoya S, McDuffy S, Alarcon-Segovia D, Pope R M
Clin Exp Immunol. 1982 May;48(2):339-47.
In order to characterize the immune complexes detected in patients with Sjogren's syndrome (SS) and with rheumatoid arthritis (RA), the sera of 19 patients with SS alone and 11 with SS plus RA were examined. Elevated quantities of circulating immune complexes (CIC) were detected in 67% by the C1q-binding assay (C1q-BA), 73% by the C1q-solid phase (C1q-SP) assay, 43% by the monoclonal rheumatoid factor solid phase assay (mRF-SP) and 33% by the mRF-inhibition assay (MRF-Inh). Elevated concentrations of IgM RF were detected in 83% and of IgG RF in 73% of the sera by radioimmunoassay. Strong correlations existed between RF of the IgM and IgG classes and both the C1q-BA and the C1q-SP. Three lines of evidence indicated that RF were important components of the immune complexes detected by these radioimmunoassays. These results indicated that in those patients with RA plus SS, as well as those with SS alone, both IgM and IgG RF made substantial contributions to immune complexes detected both by C1q-BA and C1q-SP.
为了对干燥综合征（SS）患者和类风湿关节炎（RA）患者体内检测到的免疫复合物进行特征分析，我们检测了19例单纯SS患者和11例SS合并RA患者的血清。通过C1q结合试验（C1q-BA）检测到67%的患者循环免疫复合物（CIC）水平升高，通过C1q固相试验（C1q-SP）检测到73%的患者升高，通过单克隆类风湿因子固相试验（mRF-SP）检测到43%的患者升高，通过mRF抑制试验（MRF-Inh）检测到33%的患者升高。通过放射免疫测定法，在83%的血清中检测到IgM RF浓度升高，在73%的血清中检测到IgG RF浓度升高。IgM和IgG类别的RF与C1q-BA和C1q-SP之间均存在强相关性。三条证据表明RF是这些放射免疫测定法检测到的免疫复合物的重要组成部分。这些结果表明，在那些RA合并SS的患者以及单纯SS患者中，IgM和IgG RF对通过C1q-BA和C1q-SP检测到的免疫复合物都有重要贡献。
