Liu Yani, Deng Youbin, Li Xiulan, Chang Qing, Lu Yongping, Li Chunlei
Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
J Huazhong Univ Sci Technolog Med Sci. 2005;25(6):703-5. doi: 10.1007/BF02896176.
To assess the left ventricular longitudinal regional myocardial systolic function by strain imaging (SI) echocardiography and to study the relationship between regional myocardial systolic function and left ventricular structure in patients with hypertrophic cardiomyopathy (HCM). SI echocardiography were performed in 18 patients with HCM and 17 healthy subjects. For each wall, regional myocardial systolic strain was analyzed at the basal, mid, and apical level respectively. And the peak systolic strain was measured. Our results showed that the patients with HCM had reduced peak systolic strain at almost each segment of different walls when compared with healthy subjects. There was significant correlation between the mid-septum peak systolic strain and the thickness of IVS, so was the correlation between the mid-septum peak systolic strain and the IVS to LVPW thickness ratio. This study demonstrated that the left ventricular longitudinal regional myocardial systolic function was abnormal in HCM, and this kind of abnormalities existed extensively in hypertrophic and non-hypertrophic cardiac segments. The degrees of left ventricle hypertrophy and asymmetry are related to the myocardial regional systolic function in HCM.
通过应变成像（SI）超声心动图评估肥厚型心肌病（HCM）患者左心室纵向局部心肌收缩功能，并研究局部心肌收缩功能与左心室结构之间的关系。对18例HCM患者和17名健康受试者进行了SI超声心动图检查。对于每个心室壁，分别在基底、中间和心尖水平分析局部心肌收缩应变，并测量收缩期峰值应变。我们的结果显示，与健康受试者相比，HCM患者几乎在不同心室壁的每个节段收缩期峰值应变均降低。室间隔中间水平收缩期峰值应变与室间隔厚度之间存在显著相关性，室间隔中间水平收缩期峰值应变与室间隔与左心室后壁厚度比值之间也存在显著相关性。本研究表明，HCM患者左心室纵向局部心肌收缩功能异常，且这种异常广泛存在于肥厚和非肥厚心肌节段。HCM患者左心室肥厚程度和不对称性与心肌局部收缩功能有关。
