Zhang Mingchang, Wang Li, Wang Yong, Ding Zhengping, Mai Caikeng, Nie Shaosong, Chen Fei
Department of Ophthalmology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China.
J Huazhong Univ Sci Technolog Med Sci. 2005;25(6):732-4. doi: 10.1007/BF02896186.
To evaluate the inhibiting effect of Homoharringtonine (HHT) on the corneal haze after excimer laser photorefractive keratectomy (PRK) in rabbits. 18 healthy rabbits which underwent PRK were randomly divided into three groups (A, B and C). The refractive degree of ablation was - 10.0DS in each group. Group A was locally treated with a piece of filter paper soaked with 1 mg/mL HHT for 5 min, and then the entire cornea was repeatedly irrigated with balance solution; Group B was dropped with 0.1 mg/mL HHT after PRK for 3 months; Group C was the control group. Corneal haze, histopathology, response, ect. were investigated. The corneal haze was significantly less in group A, while the difference between group B and group C was insignificant. Keratocytes and fibrocytes in corneal stroma were more active up to 3 months in group B and group C. Intraoperative use of topical HHT can reduce corneal haze after PRK in rabbits.
评估高三尖杉酯碱（HHT）对兔准分子激光屈光性角膜切削术（PRK）后角膜混浊的抑制作用。将18只接受PRK的健康兔随机分为三组（A、B和C组）。每组的切削屈光度均为-10.0DS。A组用浸有1mg/mL HHT的滤纸局部处理5分钟，然后用平衡液反复冲洗整个角膜；B组在PRK术后3个月滴入0.1mg/mL HHT；C组为对照组。对角膜混浊、组织病理学、反应等进行研究。A组角膜混浊明显较少，而B组和C组之间差异不显著。B组和C组角膜基质中的角膜细胞和成纤维细胞在术后3个月内更活跃。术中局部使用HHT可减少兔PRK术后的角膜混浊。
