Cheng Elaine, Ho Margie, Ganz Cindy, Shaha Ashok, Boyle Jay O, Singh Bhuvanesh, Wong Richard J, Patel Snehal, Shah Jatin, Branski Ryan C, Kraus Dennis H
Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York City, NY 10021, USA.
Ear Nose Throat J. 2006 Apr;85(4):262, 264-7.
The current study retrospectively reviewed the cases of 68 patients who had undergone total laryngectomy and tracheoesophageal puncture (TEP) over a 16-year period. Fifty-one patients underwent primary TEP and 17 underwent secondary TEP. Nearly 80% of patients who received TEP at the time of laryngectomy achieved excellent voice quality perceptually. In contrast, only 50% of secondary TEP patients achieved excellent voice ratings. This difference was statistically robust (p = 0.03). Although both surgical and prosthesis-related complications occurred more frequently following primary TEP, statistically significant differences were not achieved. Neither pre- nor postoperative radiotherapy had any effect on voice restoration or complication rates. Based on these data, primary TEP may be preferable for several reasons, including a greater likelihood of successful voice restoration, a shorter duration of postoperative aphonia, and the elimination of the need for a second operation and interim tube feedings.
本研究回顾性分析了68例在16年间接受全喉切除术及气管食管穿刺(TEP)的患者病例。51例患者接受一期TEP,17例接受二期TEP。在喉切除时接受TEP的患者中,近80%在主观上获得了优秀的嗓音质量。相比之下,二期TEP患者中只有50%获得了优秀的嗓音评分。这种差异具有统计学显著性(p = 0.03)。虽然一期TEP后手术及与假体相关的并发症发生率更高,但未达到统计学显著性差异。术前及术后放疗对嗓音恢复或并发症发生率均无影响。基于这些数据,一期TEP可能更可取,原因有几个,包括嗓音恢复成功的可能性更大、术后失音持续时间更短,以及无需二次手术和临时鼻饲。