Rawstron S A, Bromberg K
Department of Pediatrics, Children's Medical Center of Brooklyn, Kings County Hospital Center, NY.
Am J Dis Child. 1991 Dec;145(12):1383-8. doi: 10.1001/archpedi.1991.02160120051018.
To compare the cord blood, newborn serum, and maternal serum for the diagnosis of congenital syphilis.
Retrospective chart review.
Kings County Hospital Center, Brooklyn, NY.
Three hundred forty-eight mother-newborn pairs with positive syphilis serology.
One hundred fifteen newborns (33%) had rapid plasma reagin tests of cord blood that were nonreactive. Their mothers had positive serologic findings. There were 10% false-positive cord blood samples (cord blood rapid plasma reagin tests reactive, newborn serum rapid plasma reagin tests nonreactive) and 5% false-negative cord blood samples (cord rapid plasma reagin tests nonreactive, newborn serum rapid plasma reagin tests reactive). Thirty-three newborns had congenital syphilis. Seven newborns had cord titers fourfold higher than their mothers'; only four of these newborns had congenital syphilis. Maternal serology is superior to cord blood analysis for identifying newborns at risk of congenital syphilis.
比较脐血、新生儿血清和母体血清用于先天性梅毒诊断的情况。
回顾性病历审查。
纽约布鲁克林的国王郡医院中心。
348对梅毒血清学检查呈阳性的母婴。
115名新生儿（33%）的脐血快速血浆反应素试验呈阴性。其母亲的血清学检查结果为阳性。有10%的脐血样本出现假阳性（脐血快速血浆反应素试验呈阳性，新生儿血清快速血浆反应素试验呈阴性），5%的脐血样本出现假阴性（脐血快速血浆反应素试验呈阴性，新生儿血清快速血浆反应素试验呈阳性）。33名新生儿患有先天性梅毒。7名新生儿的脐血滴度比其母亲高四倍；其中只有4名新生儿患有先天性梅毒。在识别有先天性梅毒风险的新生儿方面，母体血清学检查优于脐血分析。
