Gunson H H, Rawlinson V I
North Western Regional Transfusion Centre, Manchester.
CDR (Lond Engl Rev). 1991 Dec 6;1(13):R144-6.
One hundred and ninety HIV-1 antibody positive donors have been detected, out of 14.85 million blood donations screened in the United Kingdom and the Isle of Man, since the start of testing in October 1985 to the end of March 1991. There were 145 men and 45 women, with an overall seropositivity rate of 0.001%. Records for new donors (ie, those donating for the first time) have been kept since February 1986 and 79 out of 1.9 million donations have been seropositive (58 men and 21 women); a rate of 0.004%. One hundred and forty-one (74.2%) of the 190 positive donors were found to have been exposed to a high risk of HIV infection. Twenty-four (13%) denied any exposure other than heterosexual intercourse with partners who were not considered to be at high risk. In six cases the partners were from countries where the main route of transmission is heterosexual. Seven donors (4%) attributed infection to some other cause. Eighteen (9.5%) have been lost to follow-up, are still being investigated or have not yet been interviewed. Combined tests which screen for both HIV-1 and HIV-2 antibodies were introduced in June 1990. The last 2.55 million donations (including 370,000 new donors) have been tested with these kits. One HIV-2 antibody positive donation had been confirmed in a new donor by the end of March 1991.(ABSTRACT TRUNCATED AT 250 WORDS)
自1985年10月开始检测至1991年3月底，在英国和马恩岛筛查的1485万份血液中，已检测出190名HIV-1抗体阳性献血者。其中男性145名，女性45名，总体血清阳性率为0.001%。自1986年2月起保存新献血者（即首次献血者）的记录，在190万份献血中有79份呈血清阳性（男性58名，女性21名）；阳性率为0.004%。190名阳性献血者中有141名（74.2%）被发现有感染HIV的高风险暴露史。24名（13%）否认有除与不被认为是高风险的性伴侣进行异性性行为之外的任何暴露史。在6例中，其性伴侣来自以异性传播为主要传播途径的国家。7名献血者（4%）将感染归因于其他原因。18名（9.5%）失访、仍在调查中或尚未接受询问。1990年6月引入了同时筛查HIV-1和HIV-2抗体的联合检测。截至1991年3月底，最后255万份献血（包括37万名新献血者）已用这些试剂盒进行检测。一名新献血者的血液被确认为HIV-2抗体阳性。
