Hancock Robert E W, Brown Kelly L, Mookherjee Neeloffer
Department of Microbiology and Immunology, University of British Columbia, 2259 Lower Mall, Vancouver, BC, Canada V6T 1Z4.
Immunobiology. 2006;211(4):315-22. doi: 10.1016/j.imbio.2005.10.017. Epub 2006 Apr 17.
Cationic antimicrobial (host defence) peptides are found as potent components of the innate immune system of all invertebrates in which they have been investigated. They vary substantially in their amino acid sequences, secondary structures, inducibility, potency and antimicrobial activity spectra. This enormous diversity is providing templates for the design and development of both antibiotic peptides and peptides that selectively modulate innate immunity to increase protection against infections and sepsis.
阳离子抗菌（宿主防御）肽是所有已被研究的无脊椎动物先天免疫系统的有效组成部分。它们在氨基酸序列、二级结构、诱导性、效力和抗菌活性谱方面有很大差异。这种巨大的多样性为设计和开发抗生素肽以及选择性调节先天免疫以增强抗感染和败血症保护能力的肽提供了模板。
