骨骼的红外成像显微镜检查：法布里病小鼠模型的例证
Infrared imaging microscopy of bone: illustrations from a mouse model of Fabry disease.
作者信息
Boskey Adele L, Goldberg Michel, Kulkarni Ashok, Gomez Santiago
机构信息
Hospital for Special Surgery and Weill Medical College of Cornell University, USA.
出版信息
Biochim Biophys Acta. 2006 Jul;1758(7):942-7. doi: 10.1016/j.bbamem.2006.02.019. Epub 2006 Mar 15.
Abstract
Bone is a complex tissue whose composition and properties vary with age, sex, diet, tissue type, health and disease. In this review, we demonstrate how infrared spectroscopy and infrared spectroscopic imaging can be applied to the study of these variations. A specific example of mice with Fabry disease (a lipid storage disease) is presented in which it is demonstrated that the bones of these young animals, while showing typical spatial variation in mineral content, mineral crystal size, and collagen maturity, do not differ from the bones of age- and sex-matched wild type animals.
摘要
骨骼是一种复杂的组织，其组成和特性会随年龄、性别、饮食、组织类型、健康状况和疾病而变化。在本综述中，我们展示了红外光谱和红外光谱成像如何应用于这些变化的研究。文中给出了法布里病（一种脂质贮积病）小鼠的具体例子，结果表明，这些幼年动物的骨骼虽然在矿物质含量、矿物晶体大小和胶原蛋白成熟度方面呈现出典型的空间变化，但与年龄和性别匹配的野生型动物的骨骼并无差异。
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