Maquet D, Demoulin C, Crielaard J M
Département des Sciences de la Motricité, Unité de Médecine Physique et Kinésithérapie-Réadaptation, Université de Liège, CHU Sart-Tilman, ISEPK, Belgique.
Ann Readapt Med Phys. 2006 Jul;49(6):337-47, 418-27. doi: 10.1016/j.annrmp.2006.03.011. Epub 2006 Apr 19.
A systematic review of the literature about chronic fatigue syndrome (CFS).
A search of the Medline database (via Ovid and PubMed) with the key words chronic fatigue syndrome, diagnosis, classification, epidemiology, etiology, physiopathology, metabolism, microbiology, immunology, virology, psychology, drug therapy, rehabilitation, and therapy. The reference lists of each article were examined for additional related articles.
CFS was defined in 1988 by the US Centes for Disease Control and Prevention. The prevalence of chronic fatigue syndrome has ranged from 0.2% to 0.7% in the general population. In 1994, the definition of CFS was revised by Fukuda et al. Despite various research in several topics (e.g. infection, immune systems, neuroendocrinology, autonomic activity, neuromuscular involvement), the pathophysiology remains unknown.
CFS, with its various major clinical and functional impacts, should be associated with a "biopsychosocial model". Progressive muscular rehabilitation, combined with behavioral and cognitive treatment, is an essential part of therapy.
对有关慢性疲劳综合征（CFS）的文献进行系统综述。
通过Ovid和PubMed检索Medline数据库，检索词为慢性疲劳综合征、诊断、分类、流行病学、病因、生理病理学、代谢、微生物学、免疫学、病毒学、心理学、药物治疗、康复和治疗。检查每篇文章的参考文献列表以查找其他相关文章。
1988年美国疾病控制与预防中心对慢性疲劳综合征进行了定义。普通人群中慢性疲劳综合征的患病率在0.2%至0.7%之间。1994年，福田等人对慢性疲劳综合征的定义进行了修订。尽管在多个主题（如感染、免疫系统、神经内分泌学、自主活动、神经肌肉受累）方面进行了各种研究，但其病理生理学仍然未知。
慢性疲劳综合征具有各种主要的临床和功能影响，应与“生物心理社会模型”相关联。渐进性肌肉康复，结合行为和认知治疗，是治疗的重要组成部分。
