Lochs H, Dejong C, Hammarqvist F, Hebuterne X, Leon-Sanz M, Schütz T, van Gemert W, van Gossum A, Valentini L, Lübke H, Bischoff S, Engelmann N, Thul P
Department of Gastroenterology, Charité-Universitätsmedizin, CCM, Berlin, Germany.
Clin Nutr. 2006 Apr;25(2):260-74. doi: 10.1016/j.clnu.2006.01.007. Epub 2006 May 15.
Undernutrition as well as specific nutrient deficiencies have been described in patients with Crohn's disease (CD), ulcerative colitis (UC) and short bowel syndrome (SBS). The present guideline gives evidence-based recommendations for the indication, application and type of formula of enteral nutrition (EN) (oral nutritional supplements (ONS) or tube feeding (TF)) in these patients. It was developed in an interdisciplinary consensus-based process in accordance with officially accepted standards and is based on all relevant publications since 1985. ONS and/or TF in addition to normal food is indicated in undernourished patients with CD or CU to improve nutritional status. In active CD EN is the first line therapy in children and should be used as sole therapy in adults mainly when treatment with corticosteroids is not feasible. No significant differences have been shown in the effects of free amino acid, peptide-based and whole protein formulae for TF. In remission ONS is recommended only in steroid dependent patients in CD. In patients with SBS TF should be introduced in the adaptation phase and should be changed with progressing adaptation to ONS in addition to normal food.
克罗恩病(CD)、溃疡性结肠炎(UC)和短肠综合征(SBS)患者中存在营养不良以及特定营养素缺乏的情况。本指南针对这些患者肠内营养(EN)(口服营养补充剂(ONS)或管饲(TF))的适应证、应用及配方类型给出了循证推荐。它是在一个基于跨学科共识的过程中,依照官方认可的标准制定的,且基于1985年以来的所有相关出版物。除正常饮食外,ONS和/或TF适用于营养不良的CD或CU患者,以改善营养状况。在活动期CD中,EN是儿童的一线治疗方法,在成人中主要用于皮质类固醇治疗不可行时作为单一疗法。对于TF,游离氨基酸、基于肽和全蛋白配方的效果未显示出显著差异。在缓解期,仅推荐CD中依赖类固醇的患者使用ONS。对于SBS患者,应在适应期开始TF,并随着适应过程的进展,除正常饮食外,改为ONS。