Szymanowski Krzysztof
Department of Mother's and Child's Health, University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.
Eur J Obstet Gynecol Reprod Biol. 2007 May;132(1):107-10. doi: 10.1016/j.ejogrb.2006.04.008. Epub 2006 May 15.
In the present study we aimed to describe apoptosis patterns in eutopic endometrium in women suffering from endometriosis in order to assess its value as a marker of early forms of endometriosis, and also to try to answer whether endometriosis is caused by changes within the eutopic endometrium or whether endometriotic lesions change the characteristics of eutopic endometrium.
The study was performed on 125 women treated in Division of Reproduction. In 52 patients peritoneal endometriosis was diagnosed (I(0)-23; II(0)-29). Seventy-three patients in whom no endometriotic foci could be found at laparoscopy were qualified as the control group. Endometrial biopsy 7-9 days after ovulation was taken for assessment of apoptosis (TUNEL) and routine histology.
Apoptosis indices in the eutopic endometrium of women with endometriosis were lower compared to women without endometriosis. In the endometrial glands apoptosis indices were 2.94+/-1.66 versus 5.23+/-2.06 (p<0.01) in the group of women with and without endometriosis, respectively. In the endometrial stroma apoptosis indices were estimated at 2.04+/-1.72 in women with endometriosis and 4.12+/-1.62 in the control group (p<0.01).
The observed changes could support the hypothesis of the different properties of eutopic endometrium in endometriotic women as a causing factor of peritoneal endometriosis.
在本研究中，我们旨在描述子宫内膜异位症女性在位内膜中的凋亡模式，以评估其作为早期子宫内膜异位症标志物的价值，并试图回答子宫内膜异位症是由在位内膜的变化引起的，还是子宫内膜异位病变改变了在位内膜的特征。
该研究对在生殖科接受治疗的125名女性进行。52例患者被诊断为腹膜子宫内膜异位症（I（0）-23例；II（0）-29例）。73例在腹腔镜检查中未发现子宫内膜异位病灶的患者被纳入对照组。在排卵后7-9天进行子宫内膜活检，以评估凋亡（TUNEL法）和常规组织学。
与无子宫内膜异位症的女性相比，子宫内膜异位症女性在位内膜中的凋亡指数较低。在位内膜腺体中的凋亡指数，子宫内膜异位症组和无子宫内膜异位症组分别为2.94±1.66和5.23±2.06（p<0.01）。在位内膜间质中的凋亡指数，子宫内膜异位症女性为2.04±1.72，对照组为4.12±1.62（p<0.01）。
观察到的变化可能支持以下假设，即子宫内膜异位症女性在位内膜的不同特性是腹膜子宫内膜异位症的致病因素。
