Makrigiannakis Antonis, Minas Vassilis, Kalantaridou Sophia N, Nikas George, Chrousos George P
Laboratory of Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Crete, Heraklion 71003, Greece.
Trends Endocrinol Metab. 2006 Jul;17(5):178-85. doi: 10.1016/j.tem.2006.05.001. Epub 2006 May 15.
Implantation of the blastocyst into the endometrium is a delicately controlled process and a prerequisite for the furtherance of the mammalian species. A complex network of molecules is involved in preparing both the endometrium and blastocyst for a successful interaction. However, the exact molecular steps are poorly understood. Studies so far have shown that disruption of certain pathways results in fertility defects. Impaired implantation is currently considered to be the most important limiting factor for the establishment of viable pregnancies in assisted reproduction. It is expected that elucidating the molecular background of the process will enable accurate diagnosis and effective treatment of infertility.
囊胚植入子宫内膜是一个受到精细调控的过程，也是哺乳动物物种繁衍的前提条件。一个复杂的分子网络参与其中，使子宫内膜和囊胚都为成功的相互作用做好准备。然而，确切的分子步骤尚不清楚。迄今为止的研究表明，某些途径的破坏会导致生育缺陷。目前，植入受损被认为是辅助生殖中建立可存活妊娠的最重要限制因素。预计阐明这一过程的分子背景将有助于准确诊断和有效治疗不孕症。
