Makrigiannakis Antonis, Minas Vassilis
Laboratory of Human Reproduction, Department of Obstetrics and Gynecology, Medical School, University of Crete, Heraklion 71003, Greece.
Reprod Biomed Online. 2007 Jan;14(1):102-9. doi: 10.1016/s1472-6483(10)60771-7.
Successful embryo implantation in mammals requires the co-ordinated development of a blastocyst competent to implant and an adhesive endometrium. Given the indispensable role of implantation for the furtherance of the species, a number of molecular mechanisms have evolved to regulate the process. A variety of molecules, produced by embryo as well as maternal tissue participates in the cross-talk between the implanting blastocyst and the endometrium. The interplay between the various molecules and the routes in which they are involved is beginning to be elucidated. Because impaired implantation represents the most important limiting factor in the establishment of pregnancy, it is believed that research in the field will allow clinicians to improve the respective rates. This paper reviews certain groups of molecules that are considered to have key roles in the mechanisms of implantation.
在哺乳动物中，成功的胚胎着床需要具备着床能力的囊胚和具有黏附性的子宫内膜协调发育。鉴于着床对于物种繁衍的不可或缺的作用，已经进化出了多种分子机制来调控这一过程。胚胎以及母体组织产生的多种分子参与了着床囊胚与子宫内膜之间的相互作用。各种分子之间的相互作用及其涉及的途径正开始被阐明。由于着床受损是妊娠建立过程中最重要的限制因素，因此人们认为该领域的研究将使临床医生能够提高相应的成功率。本文综述了某些被认为在着床机制中起关键作用的分子类别。
