诊断准确性研究的Meta分析模型的统一

A unification of models for meta-analysis of diagnostic accuracy studies.

作者信息

Harbord Roger M, Deeks Jonathan J, Egger Matthias, Whiting Penny, Sterne Jonathan A C

机构信息

Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK.

出版信息

Biostatistics. 2007 Apr;8(2):239-51. doi: 10.1093/biostatistics/kxl004. Epub 2006 May 11.

Abstract

Studies of diagnostic accuracy require more sophisticated methods for their meta-analysis than studies of therapeutic interventions. A number of different, and apparently divergent, methods for meta-analysis of diagnostic studies have been proposed, including two alternative approaches that are statistically rigorous and allow for between-study variability: the hierarchical summary receiver operating characteristic (ROC) model (Rutter and Gatsonis, 2001) and bivariate random-effects meta-analysis (van Houwelingen and others, 1993), (van Houwelingen and others, 2002), (Reitsma and others, 2005). We show that these two models are very closely related, and define the circumstances in which they are identical. We discuss the different forms of summary model output suggested by the two approaches, including summary ROC curves, summary points, confidence regions, and prediction regions.

摘要

与治疗性干预研究相比,诊断准确性研究的荟萃分析需要更复杂的方法。针对诊断性研究的荟萃分析,已经提出了许多不同且明显存在差异的方法,其中包括两种在统计学上严谨且考虑了研究间变异性的替代方法:分层汇总接受者操作特征(ROC)模型(Rutter和Gatsonis,2001年)以及双变量随机效应荟萃分析(van Houwelingen等人,1993年)、(van Houwelingen等人,2002年)、(Reitsma等人,2005年)。我们表明这两种模型密切相关,并确定了它们完全相同的情况。我们讨论了这两种方法所建议的汇总模型输出的不同形式,包括汇总ROC曲线、汇总点、置信区域和预测区域。

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