Newby D E, Cowell S J, Boon N A
Department of Cardiology, Royal Infirmary, Edinburgh, UK.
Heart. 2006 Jun;92(6):729-34. doi: 10.1136/hrt.2005.066852.
Aortic stenosis is the most common adult heart valve condition seen in the Western world and its incidence continues to rise. No established disease modifying treatments retard progression of the stenotic process. Recent insights into the pathogenesis of calcific aortic stenosis suggest that the disease mimics atherosclerosis. The natural history and progression of calcific aortic stenosis are described with particular emphasis on new and emerging medical treatments that may modify the disease process. In particular, statins and angiotensin converting enzyme inhibitors appear to hold promise but definitive evidence from large clinical trials is awaited.
主动脉瓣狭窄是西方世界最常见的成人心脏瓣膜疾病,其发病率持续上升。目前尚无已证实的疾病修饰治疗方法能够延缓狭窄进程。最近对钙化性主动脉瓣狭窄发病机制的深入研究表明,该疾病类似于动脉粥样硬化。本文描述了钙化性主动脉瓣狭窄的自然病史和进展,特别强调了可能改变疾病进程的新出现的医学治疗方法。尤其是他汀类药物和血管紧张素转换酶抑制剂似乎有前景,但仍有待大型临床试验的明确证据。