作为人TRIM5α对N-嗜性鼠白血病病毒限制作用的效力决定因素的B30.2/SPRY结构域的两个表面暴露元件。
Two surface-exposed elements of the B30.2/SPRY domain as potency determinants of N-tropic murine leukemia virus restriction by human TRIM5alpha.
作者信息
Perron Michel J, Stremlau Matthew, Sodroski Joseph
机构信息
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, 44 Binney Street, JFB 824, Boston, MA 02115, USA.
出版信息
J Virol. 2006 Jun;80(11):5631-6. doi: 10.1128/JVI.00219-06.
Abstract
Human TRIM5alpha (TRIM5alpha(hu)) potently restricts N-tropic (N-MLV), but not B-tropic, murine leukemia virus in a manner dependent upon residue 110 of the viral capsid. Rhesus monkey TRIM5alpha (TRIM5alpha(rh)) inhibits N-MLV only weakly. The study of human-monkey TRIM5alpha chimerae revealed that both the v1 and v3 variable regions of the B30.2/SPRY domain contain potency determinants for N-MLV restriction. These variable regions are predicted to be surface-exposed elements on one face of the B30.2 domain. Acidic residues in v3 complement basic residue 110 of the N-MLV capsid. The results support recognition of the retroviral capsid by the TRIM5alpha B30.2 domain.
摘要
人类TRIM5α（TRIM5α(hu)）以一种依赖于病毒衣壳第110位残基的方式有效地限制N嗜性（N-MLV）而非B嗜性小鼠白血病病毒。恒河猴TRIM5α（TRIM5α(rh)）对N-MLV的抑制作用较弱。对人-猴TRIM5α嵌合体的研究表明，B30.2/SPRY结构域的v1和v3可变区均包含N-MLV限制的效力决定因素。这些可变区预计是B30.2结构域一侧的表面暴露元件。v3中的酸性残基与N-MLV衣壳的碱性残基110互补。这些结果支持TRIM5α B30.2结构域对逆转录病毒衣壳的识别。
相似文献
1
Two surface-exposed elements of the B30.2/SPRY domain as potency determinants of N-tropic murine leukemia virus restriction by human TRIM5alpha.作为人TRIM5α对N-嗜性鼠白血病病毒限制作用的效力决定因素的B30.2/SPRY结构域的两个表面暴露元件。
J Virol. 2006 Jun;80(11):5631-6. doi: 10.1128/JVI.00219-06.
2
Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction.TRIM5α 的 B30.2（SPRY）结构域中的物种特异性变异决定了人类免疫缺陷病毒限制的效力。
J Virol. 2005 Mar;79(5):3139-45. doi: 10.1128/JVI.79.5.3139-3145.2005.
3
The human TRIM5alpha restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid.人类TRIM5α限制因子介导N型嗜亲性鼠白血病病毒衣壳的脱壳加速。
J Virol. 2007 Mar;81(5):2138-48. doi: 10.1128/JVI.02318-06. Epub 2006 Nov 29.
4
A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus.一种人类TRIM5α B30.2/SPRY结构域突变体获得了限制和过早脱壳B嗜性小鼠白血病病毒的能力。
Virology. 2008 Sep 1;378(2):233-42. doi: 10.1016/j.virol.2008.05.008. Epub 2008 Jun 30.
5
Virus-specific effects of TRIM5α(rh) RING domain functions on restriction of retroviruses.TRIM5α(rh) RING 结构域功能对逆转录病毒限制的病毒特异性作用。
J Virol. 2013 Jul;87(13):7234-45. doi: 10.1128/JVI.00620-13. Epub 2013 May 1.
6
Comparative requirements for the restriction of retrovirus infection by TRIM5alpha and TRIMCyp.TRIM5α和TRIMCyp对逆转录病毒感染限制的比较要求
Virology. 2007 Dec 20;369(2):400-10. doi: 10.1016/j.virol.2007.08.032. Epub 2007 Oct 24.
7
Functional interplay between the B-box 2 and the B30.2(SPRY) domains of TRIM5alpha.TRIM5α的B盒2结构域与B30.2（SPRY）结构域之间的功能相互作用。
Virology. 2007 Sep 30;366(2):234-44. doi: 10.1016/j.virol.2007.04.022. Epub 2007 May 31.
8
All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction.TRIM5α B30.2结构域的所有三个可变区都可能对逆转录病毒限制的特异性有贡献。
J Virol. 2006 Sep;80(17):8554-65. doi: 10.1128/JVI.00688-06.
9
The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates.逆转录病毒限制因子TRIM5α的B30.2（SPRY）结构域在灵长类动物中表现出谱系特异性的长度和序列变异。
J Virol. 2005 May;79(10):6111-21. doi: 10.1128/JVI.79.10.6111-6121.2005.
10
TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells.TRIM5α介导人类细胞中对N-嗜性鼠白血病病毒的进入后阻断。
Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11827-32. doi: 10.1073/pnas.0403364101. Epub 2004 Jul 27.
引用本文的文献
1
Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races.抗病毒限制的突变弹性有利于灵长类动物 TRIM5α 在宿主-病毒进化军备竞赛中。
Elife. 2020 Sep 15;9:e59988. doi: 10.7554/eLife.59988.
2
Restriction of HIV-1 and other retroviruses by TRIM5.TRIM5 限制 HIV-1 和其他逆转录病毒。
Nat Rev Microbiol. 2019 Sep;17(9):546-556. doi: 10.1038/s41579-019-0225-2. Epub 2019 Jul 16.
3
Impact of TRIM5α in vivo.TRIM5α在体内的作用。
AIDS. 2015 Sep 10;29(14):1733-43. doi: 10.1097/QAD.0000000000000812.
4
Evolutionary and Functional Analysis of Old World Primate TRIM5 Reveals the Ancient Emergence of Primate Lentiviruses and Convergent Evolution Targeting a Conserved Capsid Interface.旧世界灵长类动物TRIM5的进化与功能分析揭示了灵长类慢病毒的古老起源以及针对保守衣壳界面的趋同进化。
PLoS Pathog. 2015 Aug 20;11(8):e1005085. doi: 10.1371/journal.ppat.1005085. eCollection 2015 Aug.
5
In silico analysis of functional single nucleotide polymorphisms in the human TRIM22 gene.人类TRIM22基因功能性单核苷酸多态性的计算机模拟分析
PLoS One. 2014 Jul 1;9(7):e101436. doi: 10.1371/journal.pone.0101436. eCollection 2014.
6
Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region.恒河猴 TRIM5α 对 HIV-1 的限制由连接区 2 中的α螺旋决定。
J Virol. 2014 Aug;88(16):8911-23. doi: 10.1128/JVI.01134-14. Epub 2014 May 28.
7
Gain-of-sensitivity mutations in a Trim5-resistant primary isolate of pathogenic SIV identify two independent conserved determinants of Trim5α specificity.在对致病性 SIV 的耐 Trim5 原发性分离物进行的获得性敏感性突变研究中，鉴定出了两个独立的保守决定簇，它们决定了 Trim5α 的特异性。
PLoS Pathog. 2013 May;9(5):e1003352. doi: 10.1371/journal.ppat.1003352. Epub 2013 May 9.
8
Virus-specific effects of TRIM5α(rh) RING domain functions on restriction of retroviruses.TRIM5α(rh) RING 结构域功能对逆转录病毒限制的病毒特异性作用。
J Virol. 2013 Jul;87(13):7234-45. doi: 10.1128/JVI.00620-13. Epub 2013 May 1.
9
A comparison of murine leukemia viruses that escape from human and rhesus macaque TRIM5αs.逃过人及恒河猴 TRIM5α 的鼠白血病病毒的比较。
J Virol. 2013 Jun;87(11):6455-68. doi: 10.1128/JVI.03425-12. Epub 2013 Mar 27.
10
Elevated rate of fixation of endogenous retroviral elements in Haplorhini TRIM5 and TRIM22 genomic sequences: impact on transcriptional regulation.灵长类动物 TRIM5 和 TRIM22 基因组序列中内源性逆转录病毒元件固定率的升高：对转录调控的影响。
PLoS One. 2013;8(3):e58532. doi: 10.1371/journal.pone.0058532. Epub 2013 Mar 14.
本文引用的文献
1
Structure of the PRYSPRY-domain: implications for autoinflammatory diseases.PRYSPRY结构域：对自身炎症性疾病的影响
FEBS Lett. 2006 Jan 9;580(1):99-106. doi: 10.1016/j.febslet.2005.11.076. Epub 2005 Dec 9.
2
Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity.负责逆转录病毒限制活性和特异性的人类三重基序5α结构域。
J Virol. 2005 Jul;79(14):8969-78. doi: 10.1128/JVI.79.14.8969-8978.2005.
3
TRIM5alpha selectively binds a restriction-sensitive retroviral capsid.TRIM5α 选择性结合一种对限制敏感的逆转录病毒衣壳。
Retrovirology. 2005 Jun 20;2:40. doi: 10.1186/1742-4690-2-40.
4
The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates.逆转录病毒限制因子TRIM5α的B30.2（SPRY）结构域在灵长类动物中表现出谱系特异性的长度和序列变异。
J Virol. 2005 May;79(10):6111-21. doi: 10.1128/JVI.79.10.6111-6121.2005.
5
Retrovirus restriction by TRIM5alpha variants from Old World and New World primates.旧世界和新世界灵长类动物的TRIM5α变体对逆转录病毒的限制作用
J Virol. 2005 Apr;79(7):3930-7. doi: 10.1128/JVI.79.7.3930-3937.2005.
6
Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction.TRIM5α 的 B30.2（SPRY）结构域中的物种特异性变异决定了人类免疫缺陷病毒限制的效力。
J Virol. 2005 Mar;79(5):3139-45. doi: 10.1128/JVI.79.5.3139-3145.2005.
7
Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain.灵长类TRIM5α的阳性选择鉴定出一个关键的物种特异性逆转录病毒限制域。
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2832-7. doi: 10.1073/pnas.0409853102. Epub 2005 Feb 2.
8
A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction.人类TRIM5α蛋白SPRY结构域中的单个氨基酸变化导致HIV-1限制。
Curr Biol. 2005 Jan 11;15(1):73-8. doi: 10.1016/j.cub.2004.12.042.
9
Genetic control of retrovirus susceptibility in mammalian cells.哺乳动物细胞中逆转录病毒易感性的遗传控制。
Annu Rev Genet. 2004;38:61-85. doi: 10.1146/annurev.genet.38.072902.094136.
10
High-resolution structure of a retroviral capsid hexameric amino-terminal domain.逆转录病毒衣壳六聚体氨基末端结构域的高分辨率结构
Nature. 2004 Sep 23;431(7007):481-5. doi: 10.1038/nature02915.
Zotero 插件