作为人TRIM5α对N-嗜性鼠白血病病毒限制作用的效力决定因素的B30.2/SPRY结构域的两个表面暴露元件。
Two surface-exposed elements of the B30.2/SPRY domain as potency determinants of N-tropic murine leukemia virus restriction by human TRIM5alpha.
作者信息
Perron Michel J, Stremlau Matthew, Sodroski Joseph
机构信息
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, 44 Binney Street, JFB 824, Boston, MA 02115, USA.
出版信息
J Virol. 2006 Jun;80(11):5631-6. doi: 10.1128/JVI.00219-06.
Abstract
Human TRIM5alpha (TRIM5alpha(hu)) potently restricts N-tropic (N-MLV), but not B-tropic, murine leukemia virus in a manner dependent upon residue 110 of the viral capsid. Rhesus monkey TRIM5alpha (TRIM5alpha(rh)) inhibits N-MLV only weakly. The study of human-monkey TRIM5alpha chimerae revealed that both the v1 and v3 variable regions of the B30.2/SPRY domain contain potency determinants for N-MLV restriction. These variable regions are predicted to be surface-exposed elements on one face of the B30.2 domain. Acidic residues in v3 complement basic residue 110 of the N-MLV capsid. The results support recognition of the retroviral capsid by the TRIM5alpha B30.2 domain.
摘要
人类TRIM5α（TRIM5α(hu)）以一种依赖于病毒衣壳第110位残基的方式有效地限制N嗜性（N-MLV）而非B嗜性小鼠白血病病毒。恒河猴TRIM5α（TRIM5α(rh)）对N-MLV的抑制作用较弱。对人-猴TRIM5α嵌合体的研究表明，B30.2/SPRY结构域的v1和v3可变区均包含N-MLV限制的效力决定因素。这些可变区预计是B30.2结构域一侧的表面暴露元件。v3中的酸性残基与N-MLV衣壳的碱性残基110互补。这些结果支持TRIM5α B30.2结构域对逆转录病毒衣壳的识别。
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