Goff Stephen P
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA.
Annu Rev Genet. 2004;38:61-85. doi: 10.1146/annurev.genet.38.072902.094136.
Host cellular genes can have profound effects on retrovirus replication. Many of these genes encode restriction factors that block virus infection; others encode positive factors that are exploited by the viruses. Recently, a number of such genes have been cloned and characterized, bringing into sharper focus the mechanisms and pathways exploited by these viruses. The major host factors involved in the early phase of the viral life cycle are discussed.
宿主细胞基因可对逆转录病毒的复制产生深远影响。其中许多基因编码可阻断病毒感染的限制因子；其他基因则编码病毒利用的正向因子。最近，一些此类基因已被克隆和表征，使这些病毒所利用的机制和途径更加清晰。本文讨论了病毒生命周期早期涉及的主要宿主因子。
