TRIM5α 选择性结合一种对限制敏感的逆转录病毒衣壳。
TRIM5alpha selectively binds a restriction-sensitive retroviral capsid.
作者信息
Sebastian Sarah, Luban Jeremy
机构信息
Department of Microbiology, Columbia University, College of Physicians and Surgeons, 701 West 168th Street, HHSC 1502, New York, New York 10032, USA.
出版信息
Retrovirology. 2005 Jun 20;2:40. doi: 10.1186/1742-4690-2-40.
TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the alpha-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for restriction is unknown. Here we show that TRIM5alpha binds retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient discrimination to account for the exquisite specificity of restriction.
TRIM5是一种强效逆转录病毒抑制剂，靶向带有特定衣壳（CA）残基的病毒。在大多数灵长类物种中，逆转录病毒限制需要TRIM5α亚型特有的C端SPRY结构域，但识别易感病毒并将其靶向限制的机制尚不清楚。在这里，我们表明TRIM5α以一种依赖SPRY的方式从去污剂处理过的病毒体中结合逆转录病毒CA，其识别能力足以解释限制作用的高度特异性。
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