Kakigi Akinobu, Takeda Taizo, Sawada Shoichi, Taguchi Daizo
Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi, Japan.
ORL J Otorhinolaryngol Relat Spec. 2006;68(5):279-82. doi: 10.1159/000093299. Epub 2006 May 12.
Changes in plasma antidiuretic hormone (p-ADH) and plasma osmolality (p-Osm) levels were studied in 63 patients with Ménière's disease before and after isosorbide administration and a glycerol test. Increments in both p-ADH and p-Osm levels were observed after isosorbide administration and the glycerol test. The p-ADH secretion appeared to be secondarily stimulated by an increase in the p-Osm level. This p-ADH level increase affects cochlear fluid homeostasis. Based on these results, we must consider both the p-Osm and p-ADH levels when treating patients with Ménière's disease by osmotic diuretics.
对63例梅尼埃病患者在服用异山梨醇和进行甘油试验前后的血浆抗利尿激素（p-ADH）和血浆渗透压（p-Osm）水平变化进行了研究。服用异山梨醇和进行甘油试验后，p-ADH和p-Osm水平均有升高。p-ADH分泌似乎是由p-Osm水平升高继发刺激的。这种p-ADH水平升高会影响耳蜗液的稳态。基于这些结果，我们在用渗透性利尿剂治疗梅尼埃病患者时必须同时考虑p-Osm和p-ADH水平。
