Aoki M, Ando K, Kuze B, Mizuta K, Hayashi T, Ito Y
Otolaryngology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Gifu 501-1194, Japan.
Clin Otolaryngol. 2005 Dec;30(6):521-5. doi: 10.1111/j.1749-4486.2005.01107.x.
An elevation of the plasma antidiuretic hormone (ADH) levels has frequently been observed in Meniere's disease patients. However, little is known regarding the mechanism behind such an elevation of ADH level in Meniere's disease patients. Therefore, we measured the plasma ADH in Meniere's disease patients and other vertigo patients to elucidate the association between the ADH levels, stress levels and the development of Meniere's symptom.
The plasma ADH levels and plasma osmotic pressure were determined in 23 definite Meniere's disease patients and 160 patients with other types of vertigo/dizziness. All participants were administered questionnaire regarding their psychological status including their stress levels.
The ADH levels of Meniere's disease patients in the acute phase (5.80 +/- 1.37 pg/mL) were significantly higher in comparison with that of Meniere's disease patients in the remission phase (2.26 +/- 0.41 pg/mL) (P < 0.05). In other peripheral vertigo patients, the ADH level in the acute phase (1.71 +/- 0.23 pg/mL) was not significantly different from that in the remission phase (1.45 +/- 0.15 pg/mL). Meniere's disease patients in the acute phase had a significantly higher stress score (114 +/- 23) than Meniere's disease patients in the remission phase (56 +/- 13) (P < 0.05). However, there was no significant correlation between their stress score and the ADH levels.
These results suggest that the elevation of the plasma ADH levels in Meniere's disease patients in the acute phase is, therefore, associated with the pathogenesis of Meniere's disease attacks rather than with stress.
梅尼埃病患者常出现血浆抗利尿激素（ADH）水平升高。然而，关于梅尼埃病患者ADH水平升高背后的机制知之甚少。因此，我们测量了梅尼埃病患者和其他眩晕患者的血浆ADH，以阐明ADH水平、应激水平与梅尼埃病症状发展之间的关联。
测定了23例确诊的梅尼埃病患者和160例其他类型眩晕/头晕患者的血浆ADH水平和血浆渗透压。所有参与者都接受了关于他们心理状态（包括应激水平）的问卷调查。
急性期梅尼埃病患者的ADH水平（5.80±1.37 pg/mL）显著高于缓解期梅尼埃病患者（2.26±0.41 pg/mL）（P<0.05）。在其他周围性眩晕患者中，急性期的ADH水平（1.71±0.23 pg/mL）与缓解期（1.45±0.15 pg/mL）无显著差异。急性期梅尼埃病患者的应激评分（114±23）显著高于缓解期梅尼埃病患者（56±13）（P<0.05）。然而，他们的应激评分与ADH水平之间无显著相关性。
这些结果表明，急性期梅尼埃病患者血浆ADH水平升高与梅尼埃病发作的发病机制有关，而非与应激有关。
