Kitano H, Kitahara M
Am J Otol. 1987 Jul;8(4):327-9.
Serum osmolality in patients with Meniere's disease was measured by a Wescore 5100B osmometer to reveal the relationship between a vertiginous attack, the effect of isosorbide, the effect of glycerol, and the osmolality. The following results were obtained: First, the osmotic pressure of the control group ranged from 275 mOsm/kg to 285 mOsm/kg, and that of the Meniere's group ranged from 270 mOsm/kg to 290 mOsm/kg. Both groups showed normal distribution, and mean values of both were 284 mOsm/kg. There was no statistically significant difference between them with regard to serum osmolality. Second, patients with values of 283 mOsm/kg or less were more often in a vertiginous attack period, and patients with values of 284 mOsm/kg or more were more often in an attack-free period. Third, patients with values of 283 mOsm/kg or less were more often in the positive glycerol test group; those with values of 284 mOsm/kg or more were more often in the negative glycerol test group. Finally, there was no significant difference in serum osmolality between patients receiving isosorbide therapy and patients given no treatment.
采用Wescore 5100B渗透压计测量梅尼埃病患者的血清渗透压，以揭示眩晕发作、异山梨醇的作用、甘油的作用与渗透压之间的关系。获得了以下结果：第一，对照组的渗透压范围为275 mOsm/kg至285 mOsm/kg，梅尼埃病组的渗透压范围为270 mOsm/kg至290 mOsm/kg。两组均呈正态分布，两者的平均值均为284 mOsm/kg。两组在血清渗透压方面无统计学显著差异。第二，渗透压值为283 mOsm/kg或更低的患者更常处于眩晕发作期，渗透压值为284 mOsm/kg或更高的患者更常处于无发作期。第三，渗透压值为283 mOsm/kg或更低的患者更常处于甘油试验阳性组；渗透压值为284 mOsm/kg或更高的患者更常处于甘油试验阴性组。最后，接受异山梨醇治疗的患者与未接受治疗的患者在血清渗透压方面无显著差异。
