Tüzüner N, Ulkü B, Uraz S, Güngen G, Demiric S, Celikoglu S
Department of Pathology, Cerrahpasa Medical School of Istanbul University.
Sarcoidosis. 1991 Mar;8(1):14-8.
T lymphocyte subsets in a positive Kveim reaction and sarcoid tissue lesions as well as peripheral blood from 16 patients with sarcoidosis were evaluated with monoclonal antibodies. The data demonstrate a redistribution of T cells from the blood to the specifically involved tissues with granulomas, i.e., sarcoid tissue lesions and positive Kveim reaction. These cells express CD2+, CD4+ phenotype as demonstrated by high CD4/CD8 ratios at the sites of positive Kveim reaction and sarcoid tissue lesions with respect to blood.
应用单克隆抗体对16例结节病患者的阳性Kveim反应、结节病组织病变以及外周血中的T淋巴细胞亚群进行了评估。数据表明，T细胞从血液重新分布到有肉芽肿形成的特定受累组织，即结节病组织病变和阳性Kveim反应部位。相对于血液而言，在阳性Kveim反应部位和结节病组织病变部位，这些细胞表现出高CD4/CD8比值，从而证明它们表达CD2+、CD4+表型。
