Hiruma Masataro
Department of Dermatology and Allergology, Juntendo University Nerima Hospital, Tokyo, Japan.
Nihon Ishinkin Gakkai Zasshi. 2006;47(2):69-73. doi: 10.3314/jjmm.47.69.
Recent progress in the epidemiology, diagnosis and treatment of onychomycosis is summarized. The risk factors of this condition were investigated, and the results of analyses of the systemic state of patients, shape of nails, blood circulation around nails, nail growth rate and causative fungi were reported. In making a diagnosis of onychomycosis, the major effect of the quality of collected nail samples on the results was reconfirmed. In addition to the KOH method and culture method, a molecular biological method was introduced. From the therapeutic perspective, 1) prevention of recurrence, 2) identification of patients with high risk of onychomycosis, and 3) attempting new treatments (development of new drugs, improvement of administration and dosage, and evaluation of combined therapy) were discussed. The effectiveness of concomitant use with nail lacquer is anticipated in combined therapy. New studies on accurate diagnosis, early detection and early stage treatment are now being undertaken.
本文总结了甲真菌病在流行病学、诊断和治疗方面的最新进展。对该病的危险因素进行了调查，并报告了对患者全身状况、指甲形状、指甲周围血液循环、指甲生长速度和致病真菌的分析结果。在诊断甲真菌病时，再次确认了所采集指甲样本质量对结果的主要影响。除了氢氧化钾（KOH）法和培养法外，还引入了分子生物学方法。从治疗角度讨论了：1）预防复发；2）识别甲真菌病高危患者；3）尝试新的治疗方法（新药研发、给药和剂量改进以及联合治疗评估）。联合治疗中预计与指甲油同时使用会有效果。目前正在开展关于准确诊断、早期检测和早期治疗的新研究。
