Barnes D, Alford-Stevens A, Birnbaum L, Kutz F W, Wood W, Patton D
Science Advisory Board, U.S. Environmental Protection Agency, Washington, DC 20460.
Qual Assur. 1991 Oct;1(1):70-81.
In December 1990 the U.S. Environmental Protection Agency sponsored a workshop to discuss the applicability of an interim "toxicity equivalency factor" (TEF) approach to assessing risks posed by exposures to complex mixtures of polychlorinated biphenyls (PCBs). The group concluded that application of the TEF approach to PCBs would be less straightforward than it was in the case of chlorinated dibenzo-p-dioxins and dibenzofurans (CDDs/CDFs). It appears that "dioxin"-like properties of some PCB congeners are amenable to a TEF treatment that is compatible with that used for CDDs/CDFs. Such a scheme also seems to have utility in assessing risks to wildlife. Other non-"dioxin"-like toxic endpoints (e.g., neurotoxicity) appear to have a different structure-activity-related mechanism-of-action that requires a separate TEF scheme. The workshop identified data gaps in toxicology and analytical chemistry that hinder adoption of proposed TEF schemes for PCBs at this time.
1990年12月，美国环境保护局主办了一次研讨会，以讨论临时“毒性当量因子”（TEF）方法在评估多氯联苯（PCBs）复杂混合物暴露所带来风险方面的适用性。该小组得出结论，将TEF方法应用于多氯联苯并不像应用于氯代二苯并 - 对 - 二恶英和二苯并呋喃（CDDs/CDFs）那样直接。一些多氯联苯同系物的“类二恶英”特性似乎适合采用与用于CDDs/CDFs的方法兼容的TEF处理方式。这样的方案在评估对野生动物的风险方面似乎也有用处。其他非“类二恶英”的毒性终点（例如神经毒性）似乎具有不同的结构 - 活性相关作用机制，这需要一个单独的TEF方案。该研讨会确定了毒理学和分析化学方面的数据空白，这些空白阻碍了目前采用提议的多氯联苯TEF方案。
