Desrues B, Delaval P, Genetet N, Pencole C, Merdrignac G, Dassonville J, L'Huillier J P, Bourguet P, Kernec J
Service de Pneumologie, Hopital Pontchaillou, Centre Hospitalier Regional et Universitaire, Rennes, France.
Sarcoidosis. 1991 Sep;8(2):129-33.
In its pulmonary form, sarcoidosis generally resolves spontaneously, but it may lead to fibrosis of the lung. The clinical, radiological and functional tests, as well as activity markers such as the serum angiotensin converting enzyme, intrathoracic uptake of 67Gallium and the cytological data provided by bronchoalveolar lavage are only the expressions at any given time of a disease which is constantly progressing and only partly express its evolutive potential. The authors studied the distribution of T-lymphocyte subsets in the peripheral blood and from bronchoalveolar lavage. 32 patients were included in the study. They were suffering from acute or chronic sarcoidosis of the mediastinum and lungs and were divided into 2 groups according to clinical, radiological and pulmonary function criteria; Group A (n = 19) included regressive forms (minimum follow up 2 years) and group B (n = 13) the progressive untreated forms. Lymphopenia with a decrease in the percentage of CD3 cells was found in both groups. The percentage of CD4 cells is significantly lower in group B (28 +/- 11%) than in group A (45 +/- 8%) (p < 0.01) or in the control population (46 +/- 8%) (p < 0.01). The percentage of CD8 cells is higher in group B (30 +/- 8%) than in group A (18 +/- 6%). This results in a CD4/CD8 ratio which is significantly reduced in group B (1 +/- 0.5) when compared with group A (2.72 +/- 0.8) (p < 0.01) and the control group (2.17 +/- 0.8) (p < 0.01), the difference between group A and the controls being minimal.(ABSTRACT TRUNCATED AT 250 WORDS)
结节病的肺部表现形式通常可自发缓解，但可能导致肺纤维化。临床、放射学和功能检查，以及诸如血清血管紧张素转换酶、67镓的胸腔内摄取量和支气管肺泡灌洗提供的细胞学数据等活动指标，都只是疾病在任何给定时间的表现，而该疾病一直在进展，这些指标仅部分体现其演变潜力。作者研究了外周血和支气管肺泡灌洗中T淋巴细胞亚群的分布。32例患者纳入研究。他们患有纵隔和肺部的急性或慢性结节病，并根据临床、放射学和肺功能标准分为两组；A组（n = 19）包括病情好转型（最短随访2年），B组（n = 13）为未经治疗的进展型。两组均发现淋巴细胞减少伴CD3细胞百分比下降。B组CD4细胞百分比（28 +/- 11%）显著低于A组（45 +/- 8%）（p < 0.01）或对照组（46 +/- 8%）（p < 0.01）。B组CD8细胞百分比（30 +/- 8%）高于A组（18 +/- 6%）。这导致B组的CD4/CD8比值（1 +/- 0.5）与A组（2.72 +/- 0.8）（p < 0.01）和对照组（2.17 +/- 0.8）（p < 0.01）相比显著降低，A组与对照组之间的差异最小。（摘要截短于250字）
