Essig Marco
Department of Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Neuroradiology. 2006 Apr;48 Suppl 1:3-8. doi: 10.1007/s00234-006-1463-3.
The challenging and multiple goals and requirements of CNS tumor imaging require optimization of the CNS imaging protocols, including selection of the optimal contrast medium. There are several gadolinium compounds available for imaging the CNS, and all of these except the compound Gd-BOPTA have nearly identical profiles. The unique protein interaction of Gd-BOPTA results in double T1 and T2 relaxivity. This article summarizes the advantages of Gd-BOPTA over conventional gadolinium compounds in both conventional and functional MR imaging. The results of recent studies in adults and pediatric patients are presented and discussed. The principal conclusion of this article is that not all contrast agents approved for MR imaging of the CNS behave in the same way. The use of the high-relaxivity agent Gd-BOPTA for morphological and functional MR imaging allows improved detection and delineation of CNS lesions compared to conventional gadolinium agents. This not only permits more confident diagnoses, but also results in a substantially improved differential diagnostic process. The higher relaxivity of Gd-BOPTA helps to optimize functional MR imaging studies e.g. perfusion MR imaging and other dynamic MR imaging protocols.
中枢神经系统（CNS）肿瘤成像面临的具有挑战性的多重目标和要求，需要优化中枢神经系统成像方案，包括选择最佳的造影剂。有几种钆化合物可用于中枢神经系统成像，除了钆贝葡胺（Gd-BOPTA）外，所有这些化合物的特性几乎相同。Gd-BOPTA独特的蛋白质相互作用导致其具有双重T1和T2弛豫率。本文总结了Gd-BOPTA在传统和功能磁共振成像方面相对于传统钆化合物的优势。介绍并讨论了近期在成人和儿科患者中的研究结果。本文的主要结论是，并非所有获批用于中枢神经系统磁共振成像的造影剂都具有相同的表现。与传统钆剂相比，使用高弛豫率的造影剂Gd-BOPTA进行形态学和功能磁共振成像，能够更好地检测和描绘中枢神经系统病变。这不仅有助于做出更可靠的诊断，还能显著改善鉴别诊断过程。Gd-BOPTA较高的弛豫率有助于优化功能磁共振成像研究，如灌注磁共振成像和其他动态磁共振成像方案。
