Essig Marco
Department of Radiology, German Cancer Research Center, INF 280 69120 Heidelberg, Germany.
Eur Radiol. 2006 Nov;16 Suppl 7:M3-7. doi: 10.1007/s10406-006-0190-5.
Numerous experimental and clinical studies have shown that the use of the high relaxivity MR contrast agent MultiHance (gadobenate dimeglumine, Gd-BOPTA; Bracco Imaging, Milan, Italy) results in improved detection, delineation and enhancement of CNS tumors compared to other available gadolinium agents. This leads not only to more confident diagnoses, but also to a substantially improved differential diagnostic process. The higher R1 and R2 relaxivities of MultiHance, deriving from the weak and transient interaction of the Gd-BOPTA contrast-effective moiety of this agent with serum albumin, help also to further optimize functional MR imaging techniques such as perfusion MRI and dynamic MR angiography. However, because the interaction between the Gd-BOPTA chelate and serum albumin affects proton relaxation times, imaging parameters need to be adapted to achieve maximum benefit from the high relaxivity of MultiHance at different magnetic field strengths. In this article we review the unique MR imaging properties of MultiHance for the assessment of brain tumors and other cerebral pathologies, and give practical information on how best to optimize MR sequence parameters to achieve the optimal contrast between normal CNS tissue and lesion.
大量实验和临床研究表明，与其他可用的钆剂相比，使用高弛豫率磁共振造影剂MultiHance（钆贝葡胺，Gd-BOPTA；意大利米兰的博莱科影像公司）可改善中枢神经系统肿瘤的检测、轮廓描绘和强化效果。这不仅能使诊断更具信心，还能显著改善鉴别诊断过程。MultiHance较高的R1和R2弛豫率源于该造影剂的Gd-BOPTA造影有效部分与血清白蛋白的微弱且短暂的相互作用，这也有助于进一步优化功能磁共振成像技术，如灌注磁共振成像和动态磁共振血管造影。然而，由于Gd-BOPTA螯合物与血清白蛋白之间的相互作用会影响质子弛豫时间，因此需要调整成像参数，以便在不同磁场强度下从MultiHance的高弛豫率中获得最大益处。在本文中，我们回顾了MultiHance在评估脑肿瘤和其他脑部病变方面独特的磁共振成像特性，并提供了关于如何最佳优化磁共振序列参数以实现正常中枢神经系统组织与病变之间最佳对比度的实用信息。
