Chow Jeffrey, Tron Victor A
Department of Laboratory Medicine and Pathology, 4B1.19 Walter C Mackenzie Health Science Centre, University of Alberta, Edmonton, AB, Canada.
J Cutan Med Surg. 2005 Dec;9(6):289-95. doi: 10.1007/s10227-005-0109-0.
Apoptosis, or programmed cell death, is an essential physiological process that controls cell numbers during physiological processes, and eliminates abnormal cells that can potentially harm an organism.
This review summarizes our current state of knowledge of apoptosis induction in skin by UV radiation.
A review of the literature was undertaken focusing on cell death in the skin secondary to UV radiation.
It is evident that a number of apoptotic pathways, both intrinsic and extrinsic, are induced following exposure to damaging UV radiation.
Although our understanding of the apoptotic processes is gradually increasing, many important aspects remain obscure. These include interconnections between pathways, wavelength-specific differences and cell type differences.
细胞凋亡，即程序性细胞死亡，是一种重要的生理过程，在生理过程中控制细胞数量，并清除可能对生物体造成潜在危害的异常细胞。
本综述总结了我们目前对紫外线辐射诱导皮肤细胞凋亡的认识。
对文献进行综述，重点关注紫外线辐射导致的皮肤细胞死亡。
显然，暴露于有害紫外线辐射后会诱导多种凋亡途径，包括内源性和外源性途径。
尽管我们对凋亡过程的理解在逐渐增加，但许多重要方面仍不清楚。这些方面包括途径之间的相互联系、波长特异性差异和细胞类型差异。
