Department of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, 310003, China.
Stem Cell Res Ther. 2020 Nov 23;11(1):491. doi: 10.1186/s13287-020-01994-z.
Photoaging is mainly induced by continuous exposure to sun light, causing multiple unwanted skin characters and accelerating skin aging. Adipose-derived stem cells(ADSCs) are promising in supporting skin repair because of their significant antioxidant capacity and strong proliferation, differentiation, and migration ability, as well as their enriched secretome containing various growth factors and cytokines. The identification of the mechanisms by which ADSCs perform these functions for photoaging has great potential to explore therapeutic applications and combat skin aging. We also review the basic mechanisms of UV-induced skin aging and recent improvement in pre-clinical applications of ADSCs associated with photoaging. Results showed that ADSCs are potential to address photoaging problem and might treat skin cancer. Compared with ADSCs alone, the secretome-based approaches and different preconditionings of ADSCs are more promising to overcome the current limitations and enhance the anti-photoaging capacity.
光老化主要由持续暴露于阳光引起，导致多种不良皮肤特征并加速皮肤衰老。脂肪来源的干细胞（ADSCs）因其具有显著的抗氧化能力和强大的增殖、分化和迁移能力，以及富含各种生长因子和细胞因子的丰富分泌组，在支持皮肤修复方面具有广阔的应用前景。ADSCs 发挥这些功能以对抗光老化的机制的鉴定具有探索治疗应用和对抗皮肤衰老的巨大潜力。我们还回顾了 UV 诱导的皮肤衰老的基本机制以及与光老化相关的 ADSCs 的临床前应用的最新进展。结果表明，ADSCs 具有解决光老化问题的潜力，并可能治疗皮肤癌。与单独使用 ADSCs 相比，基于分泌组的方法和 ADSCs 的不同预处理更有希望克服当前的局限性并增强抗光老化能力。
