Ciaffoni S, Roata C, Turrini A, Gandini A, Crocco I, Mazzi R, Malena M, Luzzati R, Aprili G
Istituto di Malattie Infettive, Verona.
Boll Ist Sieroter Milan. 1991;70(1-2):433-7.
Increased susceptibility to bacterial recurrent infection is characteristically associated with impaired B cells function but also with a defective PMN function. We studied PMN CT in 15 HIV positive drug addicts patients with persistent generalized lymphoadenopathy (PGL), in 15 symptom free HIV negative drug addicts (SFDA) and in 15 healthy blood donors to evaluate influence of HIV infection on PMN functions. CT of patients with PGL was reduced to 78% (p < 0.0001) and 75% (p < 0.00001) of CT in SFDA patients and healthy blood donors, respectively. We conclude that HIV infection causes defective PMNL CT and then it can increase susceptibility to bacterial recurrent infections in these patients.
对细菌性反复感染易感性增加的特征是与B细胞功能受损有关，但也与中性粒细胞功能缺陷有关。我们研究了15例患有持续性全身性淋巴结肿大（PGL）的HIV阳性吸毒者、15例无症状的HIV阴性吸毒者（SFDA）和15名健康献血者的中性粒细胞趋化性，以评估HIV感染对中性粒细胞功能的影响。PGL患者的趋化性分别降至SFDA患者和健康献血者趋化性的78%（p<0.0001）和75%（p<0.00001）。我们得出结论，HIV感染导致中性粒细胞趋化性缺陷，进而增加这些患者对细菌性反复感染的易感性。
