Liston Conor, Matalon Shanna, Hare Todd A, Davidson Matthew C, Casey B J
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, New York 10021, USA.
Neuron. 2006 May 18;50(4):643-53. doi: 10.1016/j.neuron.2006.04.015.
The conflict-monitoring hypothesis posits that anterior cingulate cortex (ACC) monitors conflict in information processing and recruits dorsolateral prefrontal cortex (DLPFC) to resolve competition as needed. We used fMRI to test this prediction directly in the context of a task-switching paradigm, in which subjects responded to the color or the motion of a visual stimulus. Conflict was indexed in terms of the product of activities in areas specialized for color or motion processing on a trial-by-trial basis. Here, we report that ACC and posterior parietal cortex (PPC) were sensitive to distinct forms of conflict, at the level of the response and the stimulus representation, respectively. Activity in PPC preceded increased activity in DLPFC and predicted enhanced behavioral performance on subsequent trials. These findings suggest that ACC and PPC may act in concert to detect dissociable forms of conflict and signal to DLPFC the need for increased control.
冲突监测假说认为，前扣带回皮质（ACC）监测信息处理中的冲突，并根据需要招募背外侧前额叶皮质（DLPFC）来解决竞争。我们使用功能磁共振成像（fMRI）在任务切换范式的背景下直接测试这一预测，在该范式中，受试者对视觉刺激的颜色或运动做出反应。冲突通过在逐次试验基础上专门用于颜色或运动处理的区域中的活动乘积来索引。在此，我们报告ACC和后顶叶皮质（PPC）分别在反应水平和刺激表征水平上对不同形式的冲突敏感。PPC中的活动先于DLPFC中活动的增加，并预测随后试验中的行为表现会增强。这些发现表明，ACC和PPC可能协同作用以检测可分离的冲突形式，并向DLPFC发出增加控制需求的信号。
