Peterka R J, Black F O, Schoenhoff M B
Good Samaritan Hospital and Medical Center, R. S. Dow Neurological Sciences Institute, Portland, OR 97210.
J Vestib Res. 1990;1(1):49-59.
The dynamic response properties of horizontal vestibulo-ocular reflex (VOR) were characterized in 216 human subjects ranging in age from 7 to 81 y. The effects of aging on VOR dynamics and parameter distributions that describe VOR responses to caloric and to sinusoidal rotational stimuli were determined in a putatively normal population. Caloric test parameters showed no consistent trend with age. Rotation test parameters showed declining response amplitude and slightly less compensatory response phase with increasing age. The magnitudes of these changes were not large relative to the variability within the population. The age-related trends in VOR were not consistent with the anatomic changes in the periphery reported by others that showed an increasing rate of peripheral hair cell and nerve fiber loss in subjects over 55 y. The poor correlation between physiological and anatomical data suggest that adaptive mechanisms in the central nervous system are important in maintaining the VOR.
对216名年龄在7岁至81岁之间的人类受试者的水平前庭眼反射（VOR）的动态反应特性进行了表征。在一个假定正常的人群中，确定了衰老对VOR动态以及描述VOR对冷热和正弦旋转刺激反应的参数分布的影响。冷热测试参数未显示出与年龄一致的趋势。旋转测试参数显示，随着年龄的增长，反应幅度下降，代偿反应相位略减少。相对于人群中的变异性，这些变化的幅度不大。VOR中与年龄相关的趋势与其他人报道的外周解剖学变化不一致，后者显示55岁以上受试者外周毛细胞和神经纤维的损失率增加。生理数据和解剖学数据之间的低相关性表明，中枢神经系统中的适应性机制在维持VOR方面很重要。
