Hansen H C, Gibson J M, Zangemeister W H, Kennard C
Neurological University Clinic Hamburg-Eppendorf, F.R.G.
J Vestib Res. 1990;1(2):181-6.
Eye-head movements to target steps of amplitude 3.75 degrees to 30 degrees were analyzed in 9 untreated patients with idiopathic Parkinson's disease. Testing was performed before and after the introduction of a dopamimetic drug (L-dopa or bromocriptine) and compared with 9 normal controls. The patients showed a significantly greater scatter of mean head latencies prior to treatment, although their mean latencies were not significantly prolonged. When compared to controls, the patients' head movements were of reduced peak velocity and gain. Treatment resulted in an improvement of gain but not velocity. Analysis of the frequency of gaze types showed no significant effect of treatment.
对9例未经治疗的特发性帕金森病患者进行了分析，观察其眼球-头部向幅度为3.75度至30度的目标台阶运动。在引入多巴胺能药物（左旋多巴或溴隐亭）前后进行测试，并与9名正常对照者进行比较。患者在治疗前平均头部潜伏期的离散度显著更大，尽管其平均潜伏期没有显著延长。与对照组相比，患者头部运动的峰值速度和增益降低。治疗使增益得到改善，但速度未改善。对注视类型频率的分析显示治疗没有显著效果。
