Das Sabari, Das Nibhriti, Srivastava Lalit Mohan
Department of Biochemistry, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, India.
Clin Chim Acta. 2006 Oct;372(1-2):202-5. doi: 10.1016/j.cca.2006.03.016. Epub 2006 May 15.
The susceptibility of low-density lipoprotein (LDL) to oxidation is thought to be a crucial factor responsible for atherogenesis. There is substantial evidence for a role of dietary antioxidants in the prevention of atherogenesis and the protective effect of antioxidant nutrients may be mediated through inhibition of the oxidative modification of LDL.
We performed in vitro oxidation of LDL derived from normal and hypercholesterolemic individuals in absence and presence of different doses of ascorbic acid.
The serum lipid peroxidation level was significantly increased in hypercholesterolemic patients and their LDL has shown a greater propensity towards in vitro oxidation. Hypercholesterolemic LDL required a higher amount of ascorbic acid to reduce its oxidation level as compared to LDL isolated from normocholesterolemic individuals.
This observation may be of importance in designing future studies of antioxidant supplementation in patients with hypercholesterolemia which is one of the major risk factors for atherosclerosis.
低密度脂蛋白（LDL）的氧化易感性被认为是动脉粥样硬化发生的关键因素。有大量证据表明膳食抗氧化剂在预防动脉粥样硬化中发挥作用，抗氧化营养素的保护作用可能通过抑制LDL的氧化修饰来介导。
我们在不存在和存在不同剂量抗坏血酸的情况下，对来自正常人和高胆固醇血症患者的LDL进行体外氧化。
高胆固醇血症患者的血清脂质过氧化水平显著升高，其LDL在体外氧化中表现出更大的倾向。与从正常胆固醇血症个体分离的LDL相比，高胆固醇血症LDL需要更高量的抗坏血酸来降低其氧化水平。
这一观察结果对于设计未来高胆固醇血症患者抗氧化剂补充研究可能具有重要意义，高胆固醇血症是动脉粥样硬化的主要危险因素之一。
