Chambial Shailja, Dwivedi Shailendra, Shukla Kamla Kant, John Placheril J, Sharma Praveen
Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 342005 Rajasthan India.
Department of Zoology, Centre for Advanced Studies, University of Rajasthan, Jaipur, 302004 India.
Indian J Clin Biochem. 2013 Oct;28(4):314-28. doi: 10.1007/s12291-013-0375-3. Epub 2013 Sep 1.
The recognition of vitamin C is associated with a history of an unrelenting search for the cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radical damage. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight off infections. However the significance and beneficial effect of vitamin C in respect to human disease such as cancer, atherosclerosis, diabetes, neurodegenerative disease and metal toxicity however remains equivocal. Thus further continuous uninterrupted efforts may open new vistas to understand its significance in disease management.
维生素C的发现与一段对古代出血性疾病坏血病病因不懈探索的历史相关。维生素C于1928年被分离出来，它对结缔组织的发育和维持至关重要。它在骨骼形成、伤口愈合以及牙龈健康维持方面发挥着重要作用。维生素C在许多代谢功能中发挥重要作用，包括激活B族维生素、叶酸，将胆固醇转化为胆汁酸以及将氨基酸色氨酸转化为神经递质血清素。它是一种抗氧化剂，可保护身体免受自由基损伤。它在许多疾病和病症中用作治疗剂。维生素C保护免疫系统，减轻过敏反应的严重程度并有助于抵抗感染。然而，维生素C在诸如癌症、动脉粥样硬化、糖尿病、神经退行性疾病和金属毒性等人类疾病方面的意义和有益效果仍然不明确。因此，进一步持续不断的努力可能会为理解其在疾病管理中的意义开辟新的前景。
