Gbureck U, Grübel S, Thull R, Barralet J E
Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, D-97070 Würzburg, Germany.
Acta Biomater. 2005 Nov;1(6):671-6. doi: 10.1016/j.actbio.2005.07.006. Epub 2005 Sep 15.
Amongst the many factors influencing the long-term stability of cemented hip prostheses, the interface between the implant and bone cement is considered to be one of the most susceptible to failure. Osteolysis and loosening of the implant can occur by the interaction of mechanically and/or hydrolytically induced bond failure of the metal-cement interface. In this work, an improvement of the hydrolysis resistance of the titanium-bone cement interface was obtained by cement modification with a bifunctional coupling agent combined with a tribochemical TiO2-modification of the metal surface. Methacryloxypropyl-trimethoxysilane was added as coupling agent to the PMMA monomer in concentrations between 5 and 20 wt.% followed by the testing the shear bond strength of PMMA/titanium joints before and after ageing in physiological saline solution. It was found that the hydrolysis resistance of the metal-PMMA interface could be significantly improved by the modification of the cement. At the same time, the mechanical properties (compressive and bending strength) of the modified cement were not altered by the addition of the coupling agent. The advantage of the modification of the cement matrix is an easy clinical applicability of the procedure maintaining the processing and implantation techniques of the cement material.
在影响骨水泥型髋关节假体长期稳定性的众多因素中，植入物与骨水泥之间的界面被认为是最易失效的部位之一。金属 - 骨水泥界面的机械和/或水解诱导的粘结失效相互作用可导致植入物的骨溶解和松动。在这项工作中，通过用双功能偶联剂对骨水泥进行改性，并结合对金属表面进行摩擦化学TiO₂改性，提高了钛 - 骨水泥界面的耐水解性。将甲基丙烯酰氧基丙基三甲氧基硅烷作为偶联剂以5至20 wt.%的浓度添加到PMMA单体中，然后测试在生理盐溶液中老化前后PMMA/钛接头的剪切粘结强度。结果发现，通过对骨水泥进行改性可显著提高金属 - PMMA界面的耐水解性。同时，添加偶联剂并未改变改性骨水泥的力学性能（抗压强度和抗弯强度）。骨水泥基体改性的优点是该方法临床应用简便，同时保持了骨水泥材料的加工和植入技术。
