UCL, Eastman Dental Institute, London, UK.
Acta Biomater. 2012 Jan;8(1):313-20. doi: 10.1016/j.actbio.2011.08.008. Epub 2011 Aug 17.
The aim of this study was to investigate the effect of reactive mono- and tricalcium phosphate addition on the mechanical, surface free energy, degradation and cell compatibility properties of poly(lactide-co-propylene glycol-co-lactide) dimethacrylate (PPGLDMA) thin films. Dry composites containing up to 70 wt.% filler were in a flexible rubber state at body temperature. Filler addition increased the initial strength and Young's modulus and reduced the elastic and permanent deformation under load. The polymer had high polar surface free energy, which might enable greater spread upon bone. This was significantly reduced by filler addition but not by water immersion for 7 days. The samples exhibited reduced water sorption and associated bulk degradation when compared with previous work with thicker samples. Their cell compatibility was also improved. Filler raised water sorption and degradation but improved cell proliferation. The materials are promising bone adhesive candidates for low-load-bearing areas.
本研究旨在探讨活性单和三钙磷酸盐的添加对聚（丙交酯-乙交酯-co-丙交酯）二甲基丙烯酸酯（PPGLDMA）薄膜的机械性能、表面自由能、降解和细胞相容性的影响。在体温下，含有高达 70wt%填充剂的干复合材料处于柔软的橡胶状态。填充剂的添加提高了初始强度和杨氏模量，减少了负载下的弹性和永久变形。聚合物具有高极性表面自由能，这可能使其在骨上更易扩散。填充剂的添加显著降低了这一数值，但水浸泡 7 天并没有降低。与之前较厚样本的研究相比，这些样本的水吸附和相关的体相降解减少。它们的细胞相容性也得到了改善。填充剂提高了水吸附和降解，但促进了细胞增殖。这些材料有望成为低承重区域的骨黏附候选材料。
