Delbos V, Abgueguen P, Chennebault J M, Fanello S, Pichard E
Service des Maladies Infectieuses et tropicales, Centre Hospitalier Universitaire, 4 rue Larrey, 49933 Angers Cedex 9, France.
J Infect. 2007 Jan;54(1):e47-50. doi: 10.1016/j.jinf.2006.03.031. Epub 2006 May 15.
Cytomegalovirus (CMV)-induced thrombosis has been reported in immunocompromised patients, such as transplant recipients and patients with AIDS. Recent cases also describe thrombotic phenomena in immunocompetent patients with CMV infection. Various mechanisms may explain the role of CMV in thrombosis: this virus can damage endothelial cells, activate coagulation factors, and induce production of antiphospholipid (aPL) antibodies. We present a case report of a previously healthy white woman with a pulmonary embolism associated with CMV infection and the presence of aPL antibodies, and we discuss the role of the aPL antibodies associated with CMV infection in the pathogenesis of thrombosis.
巨细胞病毒（CMV）诱导的血栓形成在免疫功能低下的患者中已有报道，如移植受者和艾滋病患者。最近的病例也描述了免疫功能正常的CMV感染患者出现的血栓形成现象。多种机制可以解释CMV在血栓形成中的作用：这种病毒可损伤内皮细胞、激活凝血因子并诱导抗磷脂（aPL）抗体的产生。我们报告了一例既往健康的白人女性病例，其患有与CMV感染及aPL抗体存在相关的肺栓塞，并讨论了与CMV感染相关的aPL抗体在血栓形成发病机制中的作用。
