Department of Hematology Oncology, National University Hospital, Singapore, Singapore.
J Med Virol. 2012 Jan;84(1):116-8. doi: 10.1002/jmv.22253.
Thrombotic manifestations of cytomegalovirus infection in immunocompetent individuals are rare. However, it has been postulated that cytomegalovirus infection can be both directly cytopathic and capable of inducing antiphospholipid antibodies due to shared "molecular mimicry" between cytomegalovirus virus antigens and antiphospholipid antibodies. The case of a previously well 30-year-old woman with primary cytomegalovirus infection complicated by splenic infarction and massive pulmonary embolus is described. The patient is unusual given the development of thromboses affecting both the arterial and venous circulation, associated with both transient anticardiolipin antibodies and persistently positive anti-β(2) glycoprotein I antibodies. The temporal relationship between the primary infection and thrombosis was suggestive of a pathogenic role for cytomegalovirus.
免疫功能正常个体的巨细胞病毒感染很少出现血栓表现。然而，有人假设巨细胞病毒感染既可以直接引起细胞病变，又可以由于巨细胞病毒病毒抗原和抗磷脂抗体之间存在“分子模拟”而诱导抗磷脂抗体。本文报道了一例以前健康的 30 岁女性，原发性巨细胞病毒感染并发脾梗死和巨大肺栓塞。该患者血栓形成累及动、静脉循环，同时伴有短暂性抗心磷脂抗体和持续性抗β(2)糖蛋白 I 抗体，这很不寻常。原发性感染与血栓形成之间的时间关系提示巨细胞病毒可能具有致病性。
