Matsumura Takayoshi, Matsumoto Akihiro, Ohno Minoru, Suzuki Shinya, Ohta Miki, Suzuki Etsu, Takenaka Katsu, Hirata Yasunobu, Fujita Toshiro, Nagai Ryozo
Department of Cardiovascular Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Am J Med Sci. 2006 May;331(5):280-3. doi: 10.1097/00000441-200605000-00010.
Although cholesterol embolism syndrome was recognized as a clinicopathologic entity more than 50 years ago, it is attracting growing attention recently. It is a multisystemic disorder in which cholesterol crystals released from atherosclerotic plaques obstruct small arterioles, resulting in local ischemia and end-organ damage. There are no established treatments, and with the limited treatment options available, it is important to make the diagnosis as early as possible. We present the case of a 68-year-old man with cholesterol embolism who had a few fluttering atheromas in the aorta, as demonstrated by transesophageal ultrasonography. The diagnosis was confirmed by skin biopsy, and treatment with statins and steroids proved effective, as renal failure progressively improved. This case emphasizes the importance of early diagnosis and shows the possible therapeutic effects of statins and steroids for patients with this syndrome.
尽管胆固醇栓塞综合征在50多年前就被确认为一种临床病理实体，但最近它正受到越来越多的关注。它是一种多系统疾病，其中动脉粥样硬化斑块释放的胆固醇晶体阻塞小动脉，导致局部缺血和终末器官损伤。目前尚无既定的治疗方法，且可用的治疗选择有限，因此尽早做出诊断很重要。我们报告了一例68岁患有胆固醇栓塞的男性病例，经食管超声检查显示其主动脉有一些飘动的动脉粥样斑块。皮肤活检证实了诊断，他汀类药物和类固醇治疗被证明是有效的，因为肾衰竭逐渐得到改善。该病例强调了早期诊断的重要性，并显示了他汀类药物和类固醇对该综合征患者可能的治疗效果。
