Reinehr T, Enriori P J, Harz K, Cowley M A, Roth C L
Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Datteln, Germany.
Int J Obes (Lond). 2006 Oct;30(10):1476-81. doi: 10.1038/sj.ijo.0803393. Epub 2006 May 16.
Little is known concerning pancreatic polypeptide (PP) in weight loss and in childhood obesity.
Fasting PP, leptin and insulin concentrations were determined in 38 obese children and compared with 35 lean children of the same age, gender and pubertal stage. Furthermore, changes of PP concentrations over a 1-year period were analyzed in the obese children participating in a weight loss intervention program.
Obese children had significantly (P<0.01) lower PP, and higher leptin and insulin levels compared to lean children. In multiple linear regression analysis, PP was significantly negatively correlated to body mass index (P<0.01), but not to leptin, insulin, age, gender and pubertal stage. Changes of PP did not significantly correlate to changes of insulin (r=0.07, P=0.343) and leptin (r=-0.02, P=0.459). The substantial weight loss in 17 children led to a significant (P<0.05) increase in PP and decrease in insulin and leptin. In the 21 children without substantial weight loss, there were no significant changes in PP, insulin and leptin.
PP concentrations are decreased in obese children and independent of age, gender, pubertal stage, leptin and insulin. The decrease of PP in obese children normalized after weight loss. Therefore, low PP concentrations reflect the overweight status, rather than cause it.
关于胰多肽（PP）在体重减轻和儿童肥胖中的情况，人们了解甚少。
测定了38名肥胖儿童的空腹PP、瘦素和胰岛素浓度，并与35名年龄、性别和青春期阶段相同的瘦儿童进行比较。此外，对参与减肥干预项目的肥胖儿童在1年期间PP浓度的变化进行了分析。
与瘦儿童相比，肥胖儿童的PP显著降低（P<0.01），瘦素和胰岛素水平升高。在多元线性回归分析中，PP与体重指数显著负相关（P<0.01），但与瘦素、胰岛素、年龄、性别和青春期阶段无关。PP的变化与胰岛素（r=0.07，P=0.343）和瘦素（r=-0.02，P=0.459）的变化无显著相关性。17名儿童的大幅体重减轻导致PP显著增加（P<0.05），胰岛素和瘦素减少。在21名体重没有大幅减轻的儿童中，PP、胰岛素和瘦素没有显著变化。
肥胖儿童的PP浓度降低，且与年龄、性别、青春期阶段、瘦素和胰岛素无关。肥胖儿童体重减轻后PP降低的情况恢复正常。因此，低PP浓度反映的是超重状态，而非导致超重的原因。
