裂解，真的令人厌恶吗？HIV介导的聚腺苷酸结合蛋白1（PABP1）的蛋白水解作用
Cleavage, a real turn-off? HIV-mediated proteolysis of PABP1.
作者信息
Collier Brian, Gray Nicola K
机构信息
MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK.
出版信息
Biochem J. 2006 Jun 1;396(2):e9-11. doi: 10.1042/bj20060545.
Abstract
In this issue of the Biochemical Journal, Alvarez and colleagues have identified PABP1 [poly(A)-binding protein 1] as a target of protease cleavage during HIV infection. The study shows that HIV-1, HIV-2 and mouse mammary tumour virus, but not other retroviruses, target PABP1 for cleavage and identifies cleavage sites within the RNA-recognition motifs and C-terminal region of the protein. This suggests that PABP1 cleavage may be important in the shut-off of host translation during HIV infection. This extends the viral families that are known to target PABP1 to include Retroviridae, suggesting that PABP1 may be a central target of viral infection.
摘要
在本期《生物化学杂志》中，阿尔瓦雷斯及其同事已确定聚腺苷酸结合蛋白1（PABP1）是HIV感染期间蛋白酶切割的一个靶点。该研究表明，HIV-1、HIV-2和小鼠乳腺肿瘤病毒会靶向切割PABP1，但其他逆转录病毒不会，并且确定了该蛋白RNA识别基序和C端区域内的切割位点。这表明PABP1切割在HIV感染期间宿主翻译的关闭过程中可能很重要。这将已知靶向PABP1的病毒家族扩展到了逆转录病毒科，表明PABP1可能是病毒感染的一个核心靶点。
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本文引用的文献
1
HIV protease cleaves poly(A)-binding protein.HIV蛋白酶切割聚腺苷酸结合蛋白。
Biochem J. 2006 Jun 1;396(2):219-26. doi: 10.1042/BJ20060108.
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Alternative mechanisms of initiating translation of mammalian mRNAs.哺乳动物mRNA起始翻译的替代机制。
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The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells.DAZL家族蛋白是与多聚腺苷酸结合蛋白（PABP）结合的蛋白，可调节生殖细胞中的翻译过程。
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Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP.聚腺苷酸尾增强内部核糖体进入位点（IRES）介导的c-myc和BiP mRNA翻译，这一过程独立于完整的真核起始因子4G（eIF4G）和聚腺苷酸结合蛋白（PABP）。
Mol Cell. 2004 Sep 24;15(6):925-35. doi: 10.1016/j.molcel.2004.08.021.
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The roles of cytoplasmic poly(A)-binding proteins in regulating gene expression: a developmental perspective.从发育角度看细胞质聚腺苷酸结合蛋白在调控基因表达中的作用
Brief Funct Genomic Proteomic. 2004 Aug;3(2):125-41. doi: 10.1093/bfgp/3.2.125.
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Calicivirus 3C-like proteinase inhibits cellular translation by cleavage of poly(A)-binding protein.杯状病毒3C样蛋白酶通过切割聚腺苷酸结合蛋白来抑制细胞翻译。
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