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口腔癌相关成纤维细胞对癌细胞系侵袭的影响

[The effect of oral carcinoma-associated fibroblasts on the invasion of carcinoma cell line].

作者信息

Lin Jing-Wen, Zhou Hong-Mei, Li Sheng-Fu, Hu Tao, Chen Qian-Ming

机构信息

Key Laboratory of Oral Biomedical Engineering, Ministry of Education, Sichuan University, Chengdu 610041, China.

出版信息

Hua Xi Kou Qiang Yi Xue Za Zhi. 2006 Apr;24(2):101-3.

PMID:16704081
Abstract

OBJECTIVE

To observe the effect of oral carcinoma-associated fibroblasts (CAFs) on the invasion of a lingual carcinoma cell line, and to elucidate the role of CAFs in oral squamous cell carcinoma (OSCC) progression.

METHODS

Matrigel was used to remodel the basement memberane, and the interaction model between primary oral CAFs and lingual carcinoma cell line Tca8113 was established by Transwell chamber to observe the effect of CAFs on the invasion of Tca8113.

RESULTS

Compared with normal fibroblasts (NFs), CAFs promoted more Tca8113 cells to penetrate Matrigel (P < 0.05).

CONCLUSION

Oral CAFs can promote the invasion of lingual carcinoma cell line Tca8113, and play a key role in OSCC progression.

摘要

目的

观察口腔癌相关成纤维细胞（CAFs）对舌癌细胞系侵袭能力的影响，阐明CAFs在口腔鳞状细胞癌（OSCC）进展中的作用。

方法

使用基质胶重塑基底膜，通过Transwell小室建立原代口腔CAFs与舌癌细胞系Tca8113的相互作用模型，观察CAFs对Tca8113侵袭能力的影响。

结果

与正常成纤维细胞（NFs）相比，CAFs能促使更多的Tca8113细胞穿透基质胶（P < 0.05）。

结论

口腔CAFs可促进舌癌细胞系Tca8113的侵袭，在OSCC进展中起关键作用。

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