Woad Kathryn J, Watkins Wendy J, Prendergast Deborah, Shelling Andrew N
Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Aust N Z J Obstet Gynaecol. 2006 Jun;46(3):242-4. doi: 10.1111/j.1479-828X.2006.00585.x.
Premature ovarian failure (POF) is a common condition, affecting approximately 1:100 women. It is characterised by amenorrhea, hypoestrogenism, and elevated gonadotrophin levels in women under the age of 40. It is often an unexpected and distressing diagnosis, which coincides with infertility and menopausal symptoms. There is a well recognised genetic basis to the development of POF. Our laboratory has identified several candidate genes associated with POF.
卵巢早衰（POF）是一种常见病症，约每100名女性中就有1人受其影响。其特征为40岁以下女性出现闭经、雌激素缺乏及促性腺激素水平升高。这一诊断往往出人意料且令人苦恼，同时伴有不孕和更年期症状。卵巢早衰的发生有着公认的遗传基础。我们实验室已鉴定出多个与卵巢早衰相关的候选基因。
