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食用燕窝可改善雷公藤多苷诱导的卵巢早衰。

Edible bird's nest improves the premature ovarian failure induced by tripterygium glycosides.

作者信息

Jiang Lin, Liu Xuncai, Deng Fenghong, Wang Yaxin, Fan Qunyan

机构信息

School of Pharmaceutical Sciences Sun Yat-Sen University Guangzhou China.

Bird's Nest Research Institute, Xiamen Yan Palace Seelong Biotechnology Co., Ltd. Xiamen China.

出版信息

Food Sci Nutr. 2024 Mar 21;12(7):4713-4722. doi: 10.1002/fsn3.4119. eCollection 2024 Jul.

DOI:10.1002/fsn3.4119
PMID:39055185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11266920/
Abstract

Premature ovarian failure (POF) is a common disease in the field of gynecological endocrinology that seriously affects the physical and mental health of patients. Previous studies found that edible bird's nest (EBN) could improve uterine function. These suggested that EBN might also have an ameliorating effect on POF. Therefore, in this study, tripterygium glycosides (TGs) were used to induce POF in rats, and the effect of EBN on the improvement of POF was investigated. After the administration of EBN for 14 days, ovarian index and uterine index, serum hormone levels, apoptosis rate of ovarian granulosa cells, follicle-stimulating hormone receptor (FSHR) protein expression level, and the histopathological examination of the ovaries were determined. It was found that administration of medium and high EBN dose groups increased the ovarian index and granular layer thickness of rats with POF. Particularly, higher follicle-stimulating hormone levels and lower corpus luteum content were observed in the high EBN dose group. In addition, there were lower luteinizing hormone levels and fewer atretic follicles but higher progesterone levels in the medium EBN dose group. These results indicated that EBN had preventive and curative effects on POF induced by TGs. Its mechanism of action might be related to the reduction of ovarian granulosa cell apoptosis, regulation of hormones and receptors, and inhibition of follicle closure.

摘要

卵巢早衰（POF）是妇科内分泌领域的一种常见疾病，严重影响患者的身心健康。以往研究发现，食用燕窝（EBN）可改善子宫功能。这些提示EBN可能对POF也有改善作用。因此，本研究采用雷公藤多苷（TGs）诱导大鼠POF，探讨EBN对改善POF的作用。给予EBN 14天后，测定卵巢指数和子宫指数、血清激素水平、卵巢颗粒细胞凋亡率、促卵泡激素受体（FSHR）蛋白表达水平以及卵巢组织病理学检查。结果发现，中、高剂量EBN给药组可增加POF大鼠的卵巢指数和颗粒层厚度。特别是，高剂量EBN组观察到较高的促卵泡激素水平和较低的黄体含量。此外，中剂量EBN组黄体生成素水平较低，闭锁卵泡较少，但孕酮水平较高。这些结果表明，EBN对TGs诱导的POF有防治作用。其作用机制可能与减少卵巢颗粒细胞凋亡、调节激素和受体以及抑制卵泡闭锁有关。

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