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人子宫内膜干/祖细胞的鉴定与表征

Identification and characterisation of human endometrial stem/progenitor cells.

作者信息

Gargett Caroline E

机构信息

Monash University Department of Obstetrics and Gynaecology and Centre for Women's Health Research, Monash Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia.

出版信息

Aust N Z J Obstet Gynaecol. 2006 Jun;46(3):250-3. doi: 10.1111/j.1479-828X.2006.00582.x.

DOI:10.1111/j.1479-828X.2006.00582.x
PMID:16704483
Abstract

The human endometrium is a dynamic, cyclically regenerating tissue. Because adult stem cells are present in other regenerative tissues, a clonal analysis of purified endometrial epithelial and stromal cells derived from hysterectomy tissue was undertaken, as a first attempt to identify and characterise endometrial stem/progenitor cells. Rare populations of epithelial and stromal cells were clonogenic. Only those cells initiating large clones, 0.09% of epithelial cells and 0.02% of stromal cells, are likely to be endometrial stem/progenitor cells.

摘要

人类子宫内膜是一种动态的、周期性再生的组织。由于成年干细胞存在于其他再生组织中,因此对来自子宫切除组织的纯化子宫内膜上皮细胞和基质细胞进行了克隆分析,这是首次尝试识别和表征子宫内膜干/祖细胞。上皮细胞和基质细胞的稀有群体具有克隆能力。只有那些能够启动大克隆的细胞,即0.09%的上皮细胞和0.02%的基质细胞,才可能是子宫内膜干/祖细胞。

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