Sugimoto M, Takahashi S, Toguchida J, Kotoura Y, Shibamoto Y, Yamamuro T
Faculty of Medicine, Kyoto University, Japan.
J Bone Joint Surg Br. 1991 May;73(3):492-7. doi: 10.1302/0301-620X.73B3.1670456.
We studied the effects of high-dose irradiation on the mechanical properties and morphology of cortical bone in rabbits for 52 weeks after a single dose of 50 Gy of electron-beam to the tibia. After four weeks, the bending strength of the irradiated bone was unchanged, but at 12 weeks, the strength had decreased significantly. At 24 weeks after irradiation mean strength was less than half of controls but by 52 weeks there was a tendency toward recovery. Similar, synchronous changes of damage and recovery were seen in cortical porosity, haematopoietic cells in the bone marrow and endosteal new bone formation.
我们研究了单次50 Gy电子束照射兔胫骨后52周内，高剂量辐射对皮质骨力学性能和形态的影响。四周后，照射骨的弯曲强度未发生变化，但在12周时，强度显著下降。照射后24周时，平均强度不到对照组的一半，但到52周时有恢复的趋势。在皮质骨孔隙率、骨髓造血细胞和骨内膜新骨形成方面也观察到了类似的、同步的损伤和恢复变化。
